Tissue expression of INTS10 - Summary - The Human Protein Atlas

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INTS10

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	INTS10
Gene description	Integrator complex subunit 10
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA039129 , HPA050570
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	INTS10 (HGNC Symbol)
Synonyms	C8orf35, FLJ10569, INT10
Description	Integrator complex subunit 10 (HGNC Symbol)
Entrez gene summary	INTS10 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Chromosome	8
Cytoband	p21.3
Chromosome location (bp)	19817140 - 19852083
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104613 (version 83.38)
Entrez gene	55174
UniProt	Q9NVR2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NVR2
Antibodypedia	INTS10 antibodies

PROTEIN BROWSER

INTS10-001	INTS10-007	INTS10-013	INTS10-015	INTS10-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INTS10-001 ENSP00000381064 ENST00000397977	Q9NVR2 [Direct mapping] Integrator complex subunit 10 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	710 aa 82.2 kDa	No	0
INTS10-007 ENSP00000430446 ENST00000523846	H0YBW3 [Direct mapping] Integrator complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	235 aa 27.4 kDa	No	0
INTS10-013 ENSP00000429534 ENST00000518799	H0YBH6 [Direct mapping] Integrator complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	153 aa 17.7 kDa	No	0
INTS10-015 ENSP00000428608 ENST00000523772	H0YB36 [Direct mapping] Integrator complex subunit 10 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	173 aa 19.9 kDa	No	0
INTS10-018 ENSP00000429117 ENST00000520670	H0YBB0 [Direct mapping] Integrator complex subunit 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016180 [snRNA processing] GO:0032039 [integrator complex] Show all	103 aa 11.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.