Expression of KLHDC4 in cancer - Summary

GENERAL INFORMATION
Gene name	KLHDC4
Gene description	Kelch domain containing 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with additional membranous expression in some tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA041665
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable) and urothelial cancer (favourable).
Pancreatic cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041665

GENE INFORMATION
Gene name	KLHDC4 (HGNC Symbol)
Synonyms	DKFZp434G0522
Description	Kelch domain containing 4 (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q24.2
Chromosome location (bp)	87696485 - 87765992
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104731 (version 83.38)
Entrez gene	54758
UniProt	Q8TBB5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TBB5
Antibodypedia	KLHDC4 antibodies

PROTEIN BROWSER

KLHDC4-001	KLHDC4-002	KLHDC4-004	KLHDC4-015	KLHDC4-019	KLHDC4-201	KLHDC4-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLHDC4-001 ENSP00000270583 ENST00000270583	Q8TBB5 [Direct mapping] Kelch domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	520 aa 57.9 kDa	No	0
KLHDC4-002 ENSP00000262530 ENST00000353170	Q8TBB5 [Direct mapping] Kelch domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	463 aa 51.5 kDa	No	0
KLHDC4-004 ENSP00000325717 ENST00000347925	Q8TBB5 [Direct mapping] Kelch domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	489 aa 54.5 kDa	No	0
KLHDC4-015 ENSP00000457990 ENST00000561825	H3BV82 [Direct mapping] Kelch domain-containing protein 4 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		174 aa 19.5 kDa	No	0
KLHDC4-019 ENSP00000455780 ENST00000562261	H3BQH3 [Direct mapping] Kelch domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	335 aa 37.2 kDa	No	0
KLHDC4-201 ENSP00000392909 ENST00000446344	Q86VH3 [Direct mapping] HCG1980662; Kelch domain-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		291 aa 30.9 kDa	No	0
KLHDC4-202 ENSP00000482433 ENST00000622456	Q9UF94 [Direct mapping] Kelch domain containing 4, isoform CRA_a; Kelch domain-containing protein 4; Putative uncharacterized protein DKFZp434G0522 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	258 aa 29.2 kDa	No	0