Expression of ADAM2 in cancer - Summary - The Human Protein Atlas

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ADAM2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAM2
Gene description	ADAM metallopeptidase domain 2
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (prostate cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in spermatids in the seminiferus ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA024621 , HPA026581 , CAB022390
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024621	HPA026581	CAB022390

GENE INFORMATION
Gene name	ADAM2 (HGNC Symbol)
Synonyms	CT15, FTNB, PH-30b, PH30
Description	ADAM metallopeptidase domain 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded protein is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]
Chromosome	8
Cytoband	p11.22
Chromosome location (bp)	39743735 - 39838289
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104755 (version 83.38)
Entrez gene	2515
UniProt	Q99965 (UniProt - Evidence at transcript level)
neXtProt	NX_Q99965
Antibodypedia	ADAM2 antibodies

PROTEIN BROWSER

ADAM2-001	ADAM2-002	ADAM2-003	ADAM2-004	ADAM2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM2-001 ENSP00000265708 ENST00000265708	Q99965 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 2 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0007155 [cell adhesion] GO:0007338 [single fertilization] GO:0007339 [binding of sperm to zona pellucida] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0008542 [visual learning] GO:0009986 [cell surface] GO:0030534 [adult behavior] GO:0032504 [multicellular organism reproduction] Show all	735 aa 82.5 kDa	Yes	1
ADAM2-002 ENSP00000429352 ENST00000521880	B4DWY7 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 2; cDNA FLJ60930, highly similar to ADAM 2 (A disintegrin and metalloproteinase domain 2) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0007229 [integrin-mediated signaling pathway] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	672 aa 75.6 kDa	Yes	1
ADAM2-003 ENSP00000343854 ENST00000347580	Q99965 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 2 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0005178 [integrin binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0007338 [single fertilization] GO:0007339 [binding of sperm to zona pellucida] GO:0007342 [fusion of sperm to egg plasma membrane] GO:0008237 [metallopeptidase activity] GO:0008270 [zinc ion binding] GO:0032504 [multicellular organism reproduction] Show all	716 aa 80.2 kDa	Yes	1
ADAM2-004 ENSP00000369182 ENST00000379853	Q6P2G0 [Direct mapping] ADAM metallopeptidase domain 2 (Fertilin beta), isoform CRA_b; ADAM2 protein; Disintegrin and metalloproteinase domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	579 aa 64.8 kDa	Yes	1
ADAM2-201 ENSP00000483607 ENST00000622267	B4DWY7 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 2; cDNA FLJ60930, highly similar to ADAM 2 (A disintegrin and metalloproteinase domain 2) Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0007229 [integrin-mediated signaling pathway] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] Show all	672 aa 75.6 kDa	Yes	1

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