Expression of MAN2B1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MAN2B1

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAN2B1
Gene description	Mannosidase, alpha, class 2B, member 1
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA041530
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041530

GENE INFORMATION
Gene name	MAN2B1 (HGNC Symbol)
Synonyms	LAMAN, MANB
Description	Mannosidase, alpha, class 2B, member 1 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that hydrolyzes terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides. Its activity is necessary for the catabolism of N-linked carbohydrates released during glycoprotein turnover and it is member of family 38 of glycosyl hydrolases. The full length protein is processed in two steps. First, a 49 aa leader sequence is cleaved off and the remainder of the protein is processed into 3 peptides of 70 kDa, 42 kDa (D) and 13/15 kDa (E). Next, the 70 kDa peptide is further processed into three peptides (A, B and C). The A, B and C peptides are disulfide-linked. Defects in this gene have been associated with lysosomal alpha-mannosidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
Chromosome	19
Cytoband	p13.13
Chromosome location (bp)	12646511 - 12666742
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104774 (version 83.38)
Entrez gene	4125
UniProt	O00754 (UniProt - Evidence at protein level)
neXtProt	NX_O00754
Antibodypedia	MAN2B1 antibodies

PROTEIN BROWSER

MAN2B1-001	MAN2B1-003	MAN2B1-012	MAN2B1-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAN2B1-001 ENSP00000395473 ENST00000456935	O00754 [Direct mapping] Lysosomal alpha-mannosidase Lysosomal alpha-mannosidase A peptide Lysosomal alpha-mannosidase B peptide Lysosomal alpha-mannosidase C peptide Lysosomal alpha-mannosidase D peptide Lysosomal alpha-mannosidase E peptide Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004559 [alpha-mannosidase activity] GO:0005537 [mannose binding] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005774 [vacuolar membrane] GO:0005975 [carbohydrate metabolic process] GO:0006013 [mannose metabolic process] GO:0006464 [cellular protein modification process] GO:0006517 [protein deglycosylation] GO:0007611 [learning or memory] GO:0008270 [zinc ion binding] GO:0015923 [mannosidase activity] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] Show all	1011 aa 113.7 kDa	Yes	0
MAN2B1-003 ENSP00000221363 ENST00000221363	O00754 [Direct mapping] Lysosomal alpha-mannosidase Lysosomal alpha-mannosidase A peptide Lysosomal alpha-mannosidase B peptide Lysosomal alpha-mannosidase C peptide Lysosomal alpha-mannosidase D peptide Lysosomal alpha-mannosidase E peptide Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds] GO:0004559 [alpha-mannosidase activity] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005774 [vacuolar membrane] GO:0005975 [carbohydrate metabolic process] GO:0006013 [mannose metabolic process] GO:0006464 [cellular protein modification process] GO:0006517 [protein deglycosylation] GO:0008270 [zinc ion binding] GO:0015923 [mannosidase activity] GO:0030246 [carbohydrate binding] GO:0070062 [extracellular exosome] Show all	1010 aa 113.6 kDa	Yes	0
MAN2B1-012 ENSP00000470533 ENST00000598876	M0QZG6 [Direct mapping] Lysosomal alpha-mannosidase Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004559 [alpha-mannosidase activity] GO:0005975 [carbohydrate metabolic process] Show all	172 aa 19.1 kDa	Yes	0
MAN2B1-014 ENSP00000470174 ENST00000486847	M0QYZ1 [Direct mapping] Lysosomal alpha-mannosidase Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0004559 [alpha-mannosidase activity] GO:0005975 [carbohydrate metabolic process] Show all	165 aa 18.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.