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KCNN4

GENERAL INFORMATION

Gene name

 KCNN4

Gene description

 Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4

Protein class

 Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (WM-115)
HPA (normal tissue):Tissue enhanced (salivary gland)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in smooth muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 2 antibodies.
HPA053841 , HPA059622
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), urothelial cancer (favourable), glioma (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Glioma p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA053841
HPA059622

GENE INFORMATION

Gene name

 KCNN4 (HGNC Symbol)

Synonyms

 hIKCa1, hKCa4, hSK4, IK, KCa3.1

Description

 Potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.31

Chromosome location (bp)

 43766533 - 43781257

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104783 (version 83.38)

Entrez gene

 3783

UniProt

 O15554 (UniProt - Evidence at protein level)

neXtProt

 NX_O15554

Antibodypedia

 KCNN4 antibodies

PROTEIN BROWSER
KCNN4-001
KCNN4-010
KCNN4-013
KCNN4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNN4-001
ENSP00000262888
ENST00000262888
O15554 [Direct mapping]
Intermediate conductance calcium-activated potassium channel protein 4
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Calcium-Activated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0005267 [potassium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0006813 [potassium ion transport]
GO:0006816 [calcium ion transport]
GO:0006820 [anion transport]
GO:0006884 [cell volume homeostasis]
GO:0006952 [defense response]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0016286 [small conductance calcium-activated potassium channel activity]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0019903 [protein phosphatase binding]
GO:0022894 [Intermediate conductance calcium-activated potassium channel activity]
GO:0030322 [stabilization of membrane potential]
GO:0043025 [neuronal cell body]
GO:0045121 [membrane raft]
GO:0045332 [phospholipid translocation]
GO:0046541 [saliva secretion]
GO:0050714 [positive regulation of protein secretion]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0071435 [potassium ion export]
GO:0071805 [potassium ion transmembrane transport]
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 427 aa
47.7 kDa 		No 6
KCNN4-010
ENSP00000471900
ENST00000598836
M0R1J0 [Direct mapping]
Intermediate conductance calcium-activated potassium channel protein 4
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0006813 [potassium ion transport]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0022894 [Intermediate conductance calcium-activated potassium channel activity]
GO:0043025 [neuronal cell body]
GO:0071805 [potassium ion transmembrane transport]
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 165 aa
18.4 kDa 		Yes 0
KCNN4-013
ENSP00000470339
ENST00000600909
M0QZ70 [Direct mapping]
Intermediate conductance calcium-activated potassium channel protein 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
GO:0022894 [Intermediate conductance calcium-activated potassium channel activity]
GO:0043025 [neuronal cell body]
GO:0071805 [potassium ion transmembrane transport]
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 59 aa
6.6 kDa 		No 0
KCNN4-201
ENSP00000485014
ENST00000615047
D1MQ08 [Direct mapping]
Intermediate conductance calcium-activated potassium channel protein 4; Small conductance calcium activated potassium channel type 4 transcript variant 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0006813 [potassium ion transport]
GO:0015269 [calcium-activated potassium channel activity]
GO:0016021 [integral component of membrane]
GO:0022894 [Intermediate conductance calcium-activated potassium channel activity]
GO:0043025 [neuronal cell body]
GO:0071805 [potassium ion transmembrane transport]
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 295 aa
33.4 kDa 		No 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.