Tissue expression of MAP4K1 - Summary - The Human Protein Atlas

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MAP4K1

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MAP4K1
Gene description	Mitogen-activated protein kinase kinase kinase kinase 1
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lymph node, spleen, tonsil)
GTEx:	Group enriched (small intestine, spleen)
FANTOM5:	Group enriched (appendix, lymph node, spleen, tonsil)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in lymphoid tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA007419 , CAB007754
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lymph node, spleen, tonsil)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (small intestine, spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (appendix, lymph node, spleen, tonsil)

GENE INFORMATION
Gene name	MAP4K1 (HGNC Symbol)
Synonyms	HPK1
Description	Mitogen-activated protein kinase kinase kinase kinase 1 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	38587641 - 38618882
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104814 (version 83.38)
Entrez gene	11184
UniProt	Q92918 (UniProt - Evidence at protein level)
neXtProt	NX_Q92918
Antibodypedia	MAP4K1 antibodies

PROTEIN BROWSER

MAP4K1-001	MAP4K1-002	MAP4K1-003	MAP4K1-004	MAP4K1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP4K1-001 ENSP00000380066 ENST00000396857	Q92918 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006950 [response to stress] GO:0007257 [activation of JUN kinase activity] GO:0007346 [regulation of mitotic cell cycle] GO:0008283 [cell proliferation] GO:0008349 [MAP kinase kinase kinase kinase activity] GO:0016020 [membrane] GO:0018105 [peptidyl-serine phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0035556 [intracellular signal transduction] GO:0042981 [regulation of apoptotic process] GO:0046777 [protein autophosphorylation] Show all	821 aa 90.4 kDa	No	0
MAP4K1-002 ENSP00000465039 ENST00000591517	Q92918 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 1 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0006950 [response to stress] GO:0007257 [activation of JUN kinase activity] GO:0007346 [regulation of mitotic cell cycle] GO:0008283 [cell proliferation] GO:0008349 [MAP kinase kinase kinase kinase activity] GO:0016020 [membrane] GO:0018105 [peptidyl-serine phosphorylation] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0035556 [intracellular signal transduction] GO:0042981 [regulation of apoptotic process] GO:0046777 [protein autophosphorylation] Show all	833 aa 91.3 kDa	No	0
MAP4K1-003 ENSP00000468164 ENST00000589130	K7ER95 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0042981 [regulation of apoptotic process] Show all	817 aa 90 kDa	No	0
MAP4K1-004 ENSP00000465774 ENST00000586296	K7EKT6 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0042981 [regulation of apoptotic process] Show all	395 aa 44.1 kDa	No	0
MAP4K1-006 ENSP00000465303 ENST00000591921	K7EJS6 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0007346 [regulation of mitotic cell cycle] GO:0031098 [stress-activated protein kinase signaling cascade] GO:0042981 [regulation of apoptotic process] Show all	525 aa 57 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.