Expression of CGB2 in cancer - Summary - The Human Protein Atlas

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CGB2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CGB2
Gene description	Chorionic gonadotropin, beta polypeptide 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Not detected
HPA (cell line):	Cell line enhanced (HMC-1, U-266/70, U-266/84)
HPA (normal tissue):	Not detected

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in placental trophoblasts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA038925 , HPA038934
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038925	HPA038934

GENE INFORMATION
Gene name	CGB2
Synonyms
Description	Chorionic gonadotropin, beta polypeptide 2 (HGNC Symbol)
Entrez gene summary	The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49031912 - 49033238
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104818 (version 83.38)
Entrez gene	114336
UniProt
neXtProt
Antibodypedia	CGB2 antibodies

PROTEIN BROWSER

CGB2-001	CGB2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CGB2-001 ENSP00000471177 ENST00000474913	M0R0E6 [Direct mapping] Choriogonadotropin subunit beta variant 2 Show all	Predicted intracellular proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	130 aa 14 kDa	No	0
CGB2-002 ENSP00000352295 ENST00000359342	H9KV56 [Direct mapping] Choriogonadotropin subunit beta variant 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	163 aa 17.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.