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NFKBIB

GENERAL INFORMATION

Gene name

 NFKBIB

Gene description

 Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression with additional cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB010447
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB010447

GENE INFORMATION

Gene name

 NFKBIB (HGNC Symbol)

Synonyms

 IKBB, TRIP9

Description

 Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 38899700 - 38908893

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104825 (version 83.38)

Entrez gene

 4793

UniProt

 Q15653 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15653

Antibodypedia

 NFKBIB antibodies

PROTEIN BROWSER
NFKBIB-001
NFKBIB-002
NFKBIB-004
NFKBIB-005
NFKBIB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NFKBIB-001
ENSP00000459728
ENST00000572515
Q15653 [Direct mapping]
NF-kappa-B inhibitor beta
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
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GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003713 [transcription coactivator activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0032481 [positive regulation of type I interferon production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
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 338 aa
35.5 kDa 		No 0
NFKBIB-002
ENSP00000312988
ENST00000313582
Q15653 [Direct mapping]
NF-kappa-B inhibitor beta
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Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003713 [transcription coactivator activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0007165 [signal transduction]
GO:0007253 [cytoplasmic sequestering of NF-kappaB]
GO:0032481 [positive regulation of type I interferon production]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0045087 [innate immune response]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0071222 [cellular response to lipopolysaccharide]
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 356 aa
37.8 kDa 		No 0
NFKBIB-004
ENSP00000461617
ENST00000576510
I3L4X3 [Direct mapping]
NF-kappa-B inhibitor beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 234 aa
25.2 kDa 		No 0
NFKBIB-005
ENSP00000458685
ENST00000575359
I3L1A4 [Direct mapping]
NF-kappa-B inhibitor beta
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 149 aa
16.5 kDa 		No 0
NFKBIB-201
ENSP00000375929
ENST00000392079
G5E9C2 [Direct mapping]
NF-kappa-B inhibitor beta
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 270 aa
29.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.