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ARHGEF18

GENERAL INFORMATION

Gene name

 ARHGEF18

Gene description

 Rho/Rac guanine nucleotide exchange factor (GEF) 18

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression in several tissues, including lymphoid tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Approved based on 1 antibody.
HPA042689
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042689

GENE INFORMATION

Gene name

 ARHGEF18 (HGNC Symbol)

Synonyms

 KIAA0521, MGC15913, P114-RhoGEF

Description

 Rho/Rac guanine nucleotide exchange factor (GEF) 18 (HGNC Symbol)

Entrez gene summary

 Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 7395113 - 7472477

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000104880 (version 83.38)

Entrez gene

 23370

UniProt

 Q6ZSZ5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6ZSZ5

Antibodypedia

 ARHGEF18 antibodies

PROTEIN BROWSER
ARHGEF18-001
ARHGEF18-002
ARHGEF18-003
ARHGEF18-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARHGEF18-001
ENSP00000352995
ENST00000359920
Q6ZSZ5 [Direct mapping]
Rho guanine nucleotide exchange factor 18
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0016324 [apical plasma membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030054 [cell junction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045177 [apical part of cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
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 1173 aa
130.8 kDa 		No 0
ARHGEF18-002
ENSP00000319200
ENST00000319670
Q6ZSZ5 [Direct mapping]
Rho guanine nucleotide exchange factor 18
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008360 [regulation of cell shape]
GO:0016324 [apical plasma membrane]
GO:0030036 [actin cytoskeleton organization]
GO:0030054 [cell junction]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043065 [positive regulation of apoptotic process]
GO:0043547 [positive regulation of GTPase activity]
GO:0045177 [apical part of cell]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051056 [regulation of small GTPase mediated signal transduction]
GO:0070062 [extracellular exosome]
GO:0097190 [apoptotic signaling pathway]
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 1015 aa
114.1 kDa 		No 0
ARHGEF18-003
ENSP00000470729
ENST00000594665
M0QZS0 [Direct mapping]
Rho guanine nucleotide exchange factor 18
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005089 [Rho guanyl-nucleotide exchange factor activity]
GO:0035023 [regulation of Rho protein signal transduction]
GO:0043547 [positive regulation of GTPase activity]
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 812 aa
91.3 kDa 		No 0
ARHGEF18-006
ENSP00000471597
ENST00000599752
M0R125 [Direct mapping]
Rho guanine nucleotide exchange factor 18
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 87 aa
9.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.