Expression of DKKL1 in cancer - Summary - The Human Protein Atlas

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DKKL1

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DKKL1
Gene description	Dickkopf-like 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Cell line enhanced (AF22, AN3-CA)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly selective cytoplasmic expression in a subset of cells in seminiferous ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA047194 , CAB025410
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047194	CAB025410

GENE INFORMATION
Gene name	DKKL1 (HGNC Symbol)
Synonyms	CT34, SGY-1
Description	Dickkopf-like 1 (HGNC Symbol)
Entrez gene summary	The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	49361783 - 49375116
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104901 (version 83.38)
Entrez gene	27120
UniProt	Q9UK85 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UK85
Antibodypedia	DKKL1 antibodies

PROTEIN BROWSER

DKKL1-001	DKKL1-002	DKKL1-003	DKKL1-004	DKKL1-005	DKKL1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DKKL1-001 ENSP00000221498 ENST00000221498	Q9UK85 [Direct mapping] Dickkopf-like protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0002230 [positive regulation of defense response to virus by host] GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0007165 [signal transduction] GO:0009653 [anatomical structure morphogenesis] GO:0045600 [positive regulation of fat cell differentiation] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	242 aa 27 kDa	Yes	0
DKKL1-002 ENSP00000472056 ENST00000597546	M0R1Q7 [Direct mapping] Dickkopf-like protein 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all		199 aa 22.3 kDa	Yes	0
DKKL1-003 ENSP00000471812 ENST00000598682	M0R1E5 [Direct mapping] Dickkopf-like protein 1 Show all	Predicted intracellular proteins Show all		137 aa 15.5 kDa	No	0
DKKL1-004 ENSP00000470676 ENST00000596402	M0QZP1 [Direct mapping] Dickkopf-like protein 1 Show all	Predicted intracellular proteins Show all		125 aa 14.3 kDa	No	0
DKKL1-005 ENSP00000472866 ENST00000597873	M0R2X7 [Direct mapping] Dickkopf-like protein 1 Show all	Predicted intracellular proteins Show all		146 aa 16.6 kDa	No	0
DKKL1-006 ENSP00000469865 ENST00000594268	M0QYJ2 [Direct mapping] Dickkopf-like protein 1 Show all	Predicted intracellular proteins Show all		100 aa 11.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.