Cell atlas - LYL1 - The Human Protein Atlas

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LYL1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	LYL1
Gene description	Lymphoblastic leukemia associated hematopoiesis regulator 1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Cell line enhanced (HMC-1, HEL, K-562, REH, NB-4)
Protein evidence	Evidence at transcript level
Main location	Localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA075004
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1, HEL, K-562, REH, NB-4) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA075004	SH-SY5Y	Golgi apparatus
	HPA075004	SK-MEL-30	No staining
	HPA075004	U-2 OS	Golgi apparatus

GENE INFORMATION
Gene name	LYL1 (HGNC Symbol)
Synonyms	bHLHa18
Description	Lymphoblastic leukemia associated hematopoiesis regulator 1 (HGNC Symbol)
Entrez gene summary	This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010]
Chromosome	19
Cytoband	p13.13
Chromosome location (bp)	13099033 - 13103161
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000104903 (version 83.38)
Entrez gene	4066
UniProt	P12980 (UniProt - Evidence at transcript level)
neXtProt	NX_P12980
Antibodypedia	LYL1 antibodies

PROTEIN BROWSER

LYL1-001	LYL1-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LYL1-001 ENSP00000264824 ENST00000264824	P12980 [Direct mapping] Protein lyl-1 Show all	Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001955 [blood vessel maturation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0030183 [B cell differentiation] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046983 [protein dimerization activity] GO:0060216 [definitive hemopoiesis] Show all	280 aa 29.9 kDa	No	0
LYL1-003 ENSP00000468122 ENST00000590974	K7ER61 [Direct mapping] Protein lyl-1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all	GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	57 aa 6.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.