Expression of CCDC130 in cancer - Summary

GENERAL INFORMATION
Gene name	CCDC130
Gene description	Coiled-coil domain containing 130
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic and membranous expression, high expression in squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA056977
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable), urothelial cancer (favourable), renal cancer (unfavourable) and pancreatic cancer (favourable).
Head and neck cancer p<0.001 Urothelial cancer p<0.001 Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA056977

GENE INFORMATION
Gene name	CCDC130 (HGNC Symbol)
Synonyms	MGC10471
Description	Coiled-coil domain containing 130 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.13
Chromosome location (bp)	13731760 - 13763296
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000104957 (version 83.38)
Entrez gene	81576
UniProt	P13994 (UniProt - Evidence at protein level)
neXtProt	NX_P13994
Antibodypedia	CCDC130 antibodies

PROTEIN BROWSER

CCDC130-001	CCDC130-004	CCDC130-007	CCDC130-008	CCDC130-009	CCDC130-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC130-001 ENSP00000465776 ENST00000586600	P13994 [Direct mapping] Coiled-coil domain-containing protein 130 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0009615 [response to virus] Show all	396 aa 44.8 kDa	No	0
CCDC130-004 ENSP00000221554 ENST00000221554	P13994 [Direct mapping] Coiled-coil domain-containing protein 130 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0009615 [response to virus] Show all	396 aa 44.8 kDa	No	0
CCDC130-007 ENSP00000466095 ENST00000586666	K7ELI4 [Direct mapping] Coiled-coil domain-containing protein 130 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		237 aa 27.4 kDa	No	0
CCDC130-008 ENSP00000465392 ENST00000588809	K7EJZ6 [Direct mapping] Coiled-coil domain-containing protein 130 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		190 aa 21.3 kDa	No	0
CCDC130-009 ENSP00000467202 ENST00000589096	K7EP29 [Direct mapping] Coiled-coil domain-containing protein 130 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		60 aa 6.7 kDa	No	0
CCDC130-010 ENSP00000468544 ENST00000585844	K7ES43 [Direct mapping] Coiled-coil domain-containing protein 130 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		102 aa 11.8 kDa	No	0