Tissue expression of TNNT1 - Summary - The Human Protein Atlas

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TNNT1

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TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	TNNT1
Gene description	Troponin T type 1 (skeletal, slow)
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (skeletal muscle)
GTEx:	Tissue enriched (skeletal muscle)
FANTOM5:	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression

Selective cytoplasmic expression in skeletal muscle.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA058448
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

Skeletal muscle

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (skeletal muscle)

GENE INFORMATION
Gene name	TNNT1 (HGNC Symbol)
Synonyms	ANM, FLJ98147, MGC104241, NEM5, STNT, TNT, TNTS
Description	Troponin T type 1 (skeletal, slow) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is a subunit of troponin, which is a regulatory complex located on the thin filament of the sarcomere. This complex regulates striated muscle contraction in response to fluctuations in intracellular calcium concentration. This complex is composed of three subunits: troponin C, which binds calcium, troponin T, which binds tropomyosin, and troponin I, which is an inhibitory subunit. This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5, also known as Amish nemaline myopathy, a neuromuscular disorder characterized by muscle weakness and rod-shaped, or nemaline, inclusions in skeletal muscle fibers which affects infants, resulting in death due to respiratory insufficiency, usually in the second year. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.42
Chromosome location (bp)	55132794 - 55149354
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105048 (version 83.38)
Entrez gene	7138
UniProt	P13805 (UniProt - Evidence at protein level)
neXtProt	NX_P13805
Antibodypedia	TNNT1 antibodies

PROTEIN BROWSER

TNNT1-001	TNNT1-002	TNNT1-003	TNNT1-004	TNNT1-005	TNNT1-007	TNNT1-009	TNNT1-010	TNNT1-011	TNNT1-012	TNNT1-015	TNNT1-016	TNNT1-018	TNNT1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TNNT1-001 ENSP00000349233 ENST00000356783	P13805 [Direct mapping] Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0005515 [protein binding] GO:0005523 [tropomyosin binding] GO:0005829 [cytosol] GO:0005861 [troponin complex] GO:0030049 [muscle filament sliding] GO:0045932 [negative regulation of muscle contraction] Show all	251 aa 30.1 kDa	No	0
TNNT1-002 ENSP00000467176 ENST00000588981	P13805 [Direct mapping] Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0005515 [protein binding] GO:0005523 [tropomyosin binding] GO:0005829 [cytosol] GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] GO:0014883 [transition between fast and slow fiber] GO:0030049 [muscle filament sliding] GO:0031014 [troponin T binding] GO:0031444 [slow-twitch skeletal muscle fiber contraction] GO:0045932 [negative regulation of muscle contraction] Show all	278 aa 32.9 kDa	No	0
TNNT1-003 ENSP00000291901 ENST00000291901	P13805 [Direct mapping] Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0005515 [protein binding] GO:0005523 [tropomyosin binding] GO:0005829 [cytosol] GO:0005861 [troponin complex] GO:0030049 [muscle filament sliding] GO:0045932 [negative regulation of muscle contraction] Show all	262 aa 31.2 kDa	No	0
TNNT1-004 ENSP00000467299 ENST00000588147	M0QX01 [Direct mapping] Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] Show all	144 aa 17.4 kDa	No	0
TNNT1-005 ENSP00000467789 ENST00000587758	P13805 [Direct mapping] Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003009 [skeletal muscle contraction] GO:0005515 [protein binding] GO:0005523 [tropomyosin binding] GO:0005829 [cytosol] GO:0005861 [troponin complex] GO:0030049 [muscle filament sliding] GO:0045932 [negative regulation of muscle contraction] Show all	251 aa 30.1 kDa	No	0
TNNT1-007 ENSP00000465991 ENST00000588426	K7ELB0 [Direct mapping] Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] Show all	159 aa 19.2 kDa	No	0
TNNT1-009 ENSP00000470777 ENST00000593046	M0QZU8 [Direct mapping] Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] Show all	204 aa 24.4 kDa	No	0
TNNT1-010 ENSP00000470854 ENST00000589226	M0QZY5 [Direct mapping] Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] Show all	151 aa 18.2 kDa	No	0
TNNT1-011 ENSP00000467980 ENST00000585321	Q3B759 [Direct mapping] TNNT1 protein; Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] Show all	192 aa 23.1 kDa	No	0
TNNT1-012 ENSP00000464843 ENST00000587465	Q3B759 [Direct mapping] TNNT1 protein; Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] Show all	192 aa 23.1 kDa	No	0
TNNT1-015 ENSP00000467881 ENST00000593194	K7EQL4 [Direct mapping] Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] Show all	210 aa 25.2 kDa	No	0
TNNT1-016 ENSP00000465686 ENST00000589745	K7EKM3 [Direct mapping] Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] Show all	147 aa 17.3 kDa	No	0
TNNT1-018 ENSP00000469564 ENST00000586649	M0QY38 [Direct mapping] Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] Show all	104 aa 11.9 kDa	No	0
TNNT1-201 ENSP00000439640 ENST00000536926	Q3B759 [Direct mapping] TNNT1 protein; Troponin T, slow skeletal muscle Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005861 [troponin complex] GO:0006937 [regulation of muscle contraction] Show all	192 aa 23.1 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.