We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
A few cases of lung, ovarian, liver, pancreas and breast cancers showed moderate to strong cytoplasmic and nuclear positivity. Remaining cancer tissues were weakly stained or generally negative.
GENE INFORMATION
Gene name
PPP6R1 (HGNC Symbol)
Synonyms
KIAA1115, SAP190, SAPS1
Description
Protein phosphatase 6, regulatory subunit 1 (HGNC Symbol)
Entrez gene summary
Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]