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MED26

GENERAL INFORMATION

Gene name

 MED26

Gene description

 Mediator complex subunit 26

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and cervical cancer (favourable).
Renal cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 MED26 (HGNC Symbol)

Synonyms

 CRSP7, CRSP70

Description

 Mediator complex subunit 26 (HGNC Symbol)

Entrez gene summary

 The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 16574907 - 16629062

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105085 (version 83.38)

Entrez gene

 9441

UniProt

 O95402 (UniProt - Evidence at protein level)

neXtProt

 NX_O95402

Antibodypedia

 MED26 antibodies

PROTEIN BROWSER
MED26-001
MED26-002
MED26-004
MED26-005
MED26-006
MED26-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MED26-001
ENSP00000263390
ENST00000263390
O95402 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 26
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016592 [mediator complex]
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 600 aa
65.4 kDa 		No 0
MED26-002
ENSP00000484490
ENST00000611692
O95402 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 26
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001104 [RNA polymerase II transcription cofactor activity]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016592 [mediator complex]
Show all
 92 aa
10.4 kDa 		No 0
MED26-004
ENSP00000471040
ENST00000598608
M0R064 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 26
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 213 aa
23.4 kDa 		No 0
MED26-005
ENSP00000472706
ENST00000601478
M0R2P1 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 26
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 54 aa
6.3 kDa 		No 0
MED26-006
ENSP00000469434
ENST00000598492
M0QXW8 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 26
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 111 aa
12.1 kDa 		No 0
MED26-007
ENSP00000472880
ENST00000600060
M0R2Y4 [Direct mapping]
Mediator of RNA polymerase II transcription subunit 26
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
Show all
 83 aa
8.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.