Expression of OLFM2 in cancer - Summary - The Human Protein Atlas

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OLFM2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OLFM2
Gene description	Olfactomedin 2
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AN3-CA, SH-SY5Y, U-2 OS, WM-115)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA057771
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA057771

GENE INFORMATION
Gene name	OLFM2 (HGNC Symbol)
Synonyms	NOE2, OlfC
Description	Olfactomedin 2 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	9853718 - 9936552
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105088 (version 83.38)
Entrez gene	93145
UniProt	O95897 (UniProt - Evidence at protein level)
neXtProt	NX_O95897
Antibodypedia	OLFM2 antibodies

PROTEIN BROWSER

OLFM2-001	OLFM2-002	OLFM2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OLFM2-001 ENSP00000264833 ENST00000264833	O95897 [Direct mapping] Noelin-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007601 [visual perception] GO:0007626 [locomotory behavior] GO:0009306 [protein secretion] GO:0030054 [cell junction] GO:0032281 [AMPA glutamate receptor complex] GO:0051152 [positive regulation of smooth muscle cell differentiation] GO:0097060 [synaptic membrane] Show all	454 aa 51.4 kDa	Yes	0
OLFM2-002 ENSP00000464877 ENST00000590841	K7EIS8 [Direct mapping] Noelin-2 Show all	Predicted intracellular proteins Show all		376 aa 42.8 kDa	No	0
OLFM2-005 ENSP00000465809 ENST00000593091	K7EKW2 [Direct mapping] Noelin-2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		336 aa 37.6 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.