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AKAP8

GENERAL INFORMATION

Gene name

 AKAP8

Gene description

 A kinase (PRKA) anchor protein 8

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA004776
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA004776

GENE INFORMATION

Gene name

 AKAP8 (HGNC Symbol)

Synonyms

 AKAP95, DKFZp586B1222

Description

 A kinase (PRKA) anchor protein 8 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 15353385 - 15379798

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105127 (version 83.38)

Entrez gene

 10270

UniProt

 O43823 (UniProt - Evidence at protein level)

neXtProt

 NX_O43823

Antibodypedia

 AKAP8 antibodies

PROTEIN BROWSER
AKAP8-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AKAP8-004
ENSP00000269701
ENST00000269701
O43823 [Direct mapping]
A-kinase anchor protein 8
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001939 [female pronucleus]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0007067 [mitotic nuclear division]
GO:0007165 [signal transduction]
GO:0008270 [zinc ion binding]
GO:0016020 [membrane]
GO:0016363 [nuclear matrix]
GO:0034237 [protein kinase A regulatory subunit binding]
GO:0044822 [poly(A) RNA binding]
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 692 aa
76.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.