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CASP14

GENERAL INFORMATION

Gene name

 CASP14

Gene description

 Caspase 14, apoptosis-related cysteine peptidase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (cervical cancer)
HPA (cell line):Cell line enriched (hTCEpi)
HPA (normal tissue):Tissue enriched (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic and nuclear expression in skin.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA027062 , CAB010059
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Pancreatic cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (cervical cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA027062
CAB010059

GENE INFORMATION

Gene name

 CASP14 (HGNC Symbol)

Synonyms

 MGC119078, MGC119079, MICE

Description

 Caspase 14, apoptosis-related cysteine peptidase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.12

Chromosome location (bp)

 15049384 - 15058293

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105141 (version 83.38)

Entrez gene

 23581

UniProt

 P31944 (UniProt - Evidence at protein level)

neXtProt

 NX_P31944

Antibodypedia

 CASP14 antibodies

PROTEIN BROWSER
CASP14-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CASP14-001
ENSP00000393417
ENST00000427043
P31944 [Direct mapping]
Caspase-14 Caspase-14 subunit p17, mature form Caspase-14 subunit p10, mature form Caspase-14 subunit p20, intermediate form Caspase-14 subunit p8, intermediate form
B2CIS9 [Target identity:100%; Query identity:100%]
Caspase 14, apoptosis-related cysteine peptidase; Caspase-14; cDNA, FLJ94644, Homo sapiens caspase 14, apoptosis-related cysteine protease(CASP14), mRNA
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Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006508 [proteolysis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0008544 [epidermis development]
GO:0008630 [intrinsic apoptotic signaling pathway in response to DNA damage]
GO:0031424 [keratinization]
GO:0045095 [keratin filament]
GO:0070062 [extracellular exosome]
GO:0070268 [cornification]
GO:0097192 [extrinsic apoptotic signaling pathway in absence of ligand]
GO:0097199 [cysteine-type endopeptidase activity involved in apoptotic signaling pathway]
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 242 aa
27.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.