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PDCD5

GENERAL INFORMATION

Gene name

 PDCD5

Gene description

 Programmed cell death 5

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA018471
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA018471

GENE INFORMATION

Gene name

 PDCD5 (HGNC Symbol)

Synonyms

 MGC9294, TFAR19

Description

 Programmed cell death 5 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is upregulated during apoptosis where it translocates rapidly from the cytoplasm to the nucleus. The encoded protein may be an important regulator of K(lysine) acetyltransferase 5 (a protein involved in transcription, DNA damage response and cell cycle control) by inhibiting its proteasome-dependent degradation. Pseudogenes have been identified on chromosomes 5 and 12 [provided by RefSeq, Dec 2010]

Chromosome

 19

Cytoband

 q13.11

Chromosome location (bp)

 32581068 - 32587452

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105185 (version 83.38)

Entrez gene

 9141

UniProt

 O14737 (UniProt - Evidence at protein level)

neXtProt

 NX_O14737

Antibodypedia

 PDCD5 antibodies

PROTEIN BROWSER
PDCD5-001
PDCD5-002
PDCD5-003
PDCD5-006
PDCD5-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDCD5-001
ENSP00000466214
ENST00000590247
O14737 [Direct mapping]
Programmed cell death protein 5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010698 [acetyltransferase activator activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0048487 [beta-tubulin binding]
GO:0070062 [extracellular exosome]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:1903638 [positive regulation of protein import into mitochondrial outer membrane]
GO:1903645 [negative regulation of chaperone-mediated protein folding]
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 125 aa
14.3 kDa 		No 0
PDCD5-002
ENSP00000476525
ENST00000419343
O14737 [Direct mapping]
Programmed cell death protein 5
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0008201 [heparin binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010628 [positive regulation of gene expression]
GO:0010698 [acetyltransferase activator activity]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0048487 [beta-tubulin binding]
GO:0070062 [extracellular exosome]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:1903638 [positive regulation of protein import into mitochondrial outer membrane]
GO:1903645 [negative regulation of chaperone-mediated protein folding]
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 129 aa
15 kDa 		No 0
PDCD5-003
ENSP00000368620
ENST00000379316
Q3HM38 [Direct mapping]
Programmed cell death 5 short isoform; Programmed cell death protein 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
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 40 aa
4.5 kDa 		No 0
PDCD5-006
ENSP00000468741
ENST00000592786
K7ESJ4 [Direct mapping]
Programmed cell death protein 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
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 65 aa
7.5 kDa 		No 0
PDCD5-008
ENSP00000467737
ENST00000586035
K7EQA1 [Direct mapping]
Programmed cell death protein 5
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
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 87 aa
10 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.