Expression of ANKRD27 in cancer - Summary - The Human Protein Atlas

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ANKRD27

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANKRD27
Gene description	Ankyrin repeat domain 27 (VPS9 domain)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues, including smooth muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA042769
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042769

GENE INFORMATION
Gene name	ANKRD27 (HGNC Symbol)
Synonyms	DKFZp434L0718, FLJ00040, VARP
Description	Ankyrin repeat domain 27 (VPS9 domain) (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.11
Chromosome location (bp)	32597007 - 32676597
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105186 (version 83.38)
Entrez gene	84079
UniProt	Q96NW4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96NW4
Antibodypedia	ANKRD27 antibodies

PROTEIN BROWSER

ANKRD27-001	ANKRD27-002	ANKRD27-003	ANKRD27-009	ANKRD27-010	ANKRD27-011	ANKRD27-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANKRD27-001 ENSP00000304292 ENST00000306065	Q96NW4 [Direct mapping] Ankyrin repeat domain-containing protein 27 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000149 [SNARE binding] GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0015031 [protein transport] GO:0016020 [membrane] GO:0017137 [Rab GTPase binding] GO:0030133 [transport vesicle] GO:0030659 [cytoplasmic vesicle membrane] GO:0035544 [negative regulation of SNARE complex assembly] GO:0035646 [endosome to melanosome transport] GO:0042470 [melanosome] GO:0043005 [neuron projection] GO:0043547 [positive regulation of GTPase activity] GO:0045022 [early endosome to late endosome transport] GO:0048812 [neuron projection morphogenesis] GO:0050775 [positive regulation of dendrite morphogenesis] GO:0097422 [tubular endosome] GO:1990126 [retrograde transport, endosome to plasma membrane] Show all	1050 aa 117 kDa	No	0
ANKRD27-002 ENSP00000466138 ENST00000587352	K7ELM1 [Direct mapping] Ankyrin repeat domain-containing protein 27 Show all	MEMSAT3 predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] Show all	389 aa 44.6 kDa	No	0
ANKRD27-003 ENSP00000467447 ENST00000586463	K7EPM2 [Direct mapping] Ankyrin repeat domain-containing protein 27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		30 aa 3.4 kDa	No	0
ANKRD27-009 ENSP00000464751 ENST00000591100	K7EIH4 [Direct mapping] Ankyrin repeat domain-containing protein 27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	174 aa 19.5 kDa	No	0
ANKRD27-010 ENSP00000464819 ENST00000590519	K7EIN0 [Direct mapping] Ankyrin repeat domain-containing protein 27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		75 aa 8.4 kDa	No	0
ANKRD27-011 ENSP00000476897 ENST00000586693	V9GYL8 [Direct mapping] Ankyrin repeat domain-containing protein 27 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		150 aa 17 kDa	No	0
ANKRD27-201 ENSP00000480730 ENST00000622502	A0A087WX52 [Direct mapping] Ankyrin repeat domain-containing protein 27 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		174 aa 19.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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