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FBL

GENERAL INFORMATION

Gene name

 FBL

Gene description

 Fibrillarin

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nucleolar expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB001514
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and breast cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB001514

GENE INFORMATION

Gene name

 FBL (HGNC Symbol)

Synonyms

 FIB, FLRN, RNU3IP1

Description

 Fibrillarin (HGNC Symbol)

Entrez gene summary

 This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 39834458 - 39846414

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105202 (version 83.38)

Entrez gene

 2091

UniProt

 P22087 (UniProt - Evidence at protein level)

neXtProt

 NX_P22087

Antibodypedia

 FBL antibodies

PROTEIN BROWSER
FBL-001
FBL-004
FBL-005
FBL-006
FBL-009
FBL-010
FBL-011
FBL-012
FBL-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FBL-001
ENSP00000221801
ENST00000221801
P22087 [Direct mapping]
rRNA 2'-O-methyltransferase fibrillarin
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000494 [box C/D snoRNA 3'-end processing]
GO:0001649 [osteoblast differentiation]
GO:0001651 [dense fibrillar component]
GO:0001652 [granular component]
GO:0003723 [RNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0006396 [RNA processing]
GO:0008033 [tRNA processing]
GO:0008168 [methyltransferase activity]
GO:0008649 [rRNA methyltransferase activity]
GO:0015030 [Cajal body]
GO:0016020 [membrane]
GO:0016074 [snoRNA metabolic process]
GO:0031167 [rRNA methylation]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
GO:1990258 [histone glutamine methylation]
GO:1990259 [histone-glutamine methyltransferase activity]
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 321 aa
33.8 kDa 		No 0
FBL-004
ENSP00000472726
ENST00000601274
M0R2Q4 [Direct mapping]
rRNA 2'-O-methyltransferase fibrillarin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000494 [box C/D snoRNA 3'-end processing]
GO:0003723 [RNA binding]
GO:0006364 [rRNA processing]
GO:0008033 [tRNA processing]
GO:0008168 [methyltransferase activity]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
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 273 aa
29.2 kDa 		No 0
FBL-005
ENSP00000471350
ENST00000597634
M0R0P1 [Direct mapping]
rRNA 2'-O-methyltransferase fibrillarin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000494 [box C/D snoRNA 3'-end processing]
GO:0003723 [RNA binding]
GO:0006364 [rRNA processing]
GO:0008033 [tRNA processing]
GO:0008168 [methyltransferase activity]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
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 228 aa
24.5 kDa 		No 0
FBL-006
ENSP00000469249
ENST00000597224
M0QXL5 [Direct mapping]
rRNA 2'-O-methyltransferase fibrillarin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000494 [box C/D snoRNA 3'-end processing]
GO:0003723 [RNA binding]
GO:0006364 [rRNA processing]
GO:0008033 [tRNA processing]
GO:0008168 [methyltransferase activity]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
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 244 aa
26.6 kDa 		No 0
FBL-009
ENSP00000472419
ENST00000595545
M0R299 [Direct mapping]
rRNA 2'-O-methyltransferase fibrillarin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000494 [box C/D snoRNA 3'-end processing]
GO:0003723 [RNA binding]
GO:0006364 [rRNA processing]
GO:0008033 [tRNA processing]
GO:0008168 [methyltransferase activity]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
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 229 aa
25.3 kDa 		No 0
FBL-010
ENSP00000472805
ENST00000599134
M0R2U2 [Direct mapping]
rRNA 2'-O-methyltransferase fibrillarin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000494 [box C/D snoRNA 3'-end processing]
GO:0003723 [RNA binding]
GO:0006364 [rRNA processing]
GO:0008033 [tRNA processing]
GO:0008168 [methyltransferase activity]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
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 157 aa
16.2 kDa 		No 0
FBL-011
ENSP00000471867
ENST00000598417
M0R1H0 [Direct mapping]
rRNA 2'-O-methyltransferase fibrillarin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000494 [box C/D snoRNA 3'-end processing]
GO:0003723 [RNA binding]
GO:0006364 [rRNA processing]
GO:0008033 [tRNA processing]
GO:0008168 [methyltransferase activity]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
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 178 aa
18 kDa 		No 0
FBL-012
ENSP00000472433
ENST00000594309
M0R2B0 [Direct mapping]
rRNA 2'-O-methyltransferase fibrillarin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000494 [box C/D snoRNA 3'-end processing]
GO:0003723 [RNA binding]
GO:0006364 [rRNA processing]
GO:0008033 [tRNA processing]
GO:0008168 [methyltransferase activity]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
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 182 aa
18.2 kDa 		No 0
FBL-201
ENSP00000486736
ENST00000626009
A0A0D9SFM2 [Direct mapping]
rRNA 2'-O-methyltransferase fibrillarin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000494 [box C/D snoRNA 3'-end processing]
GO:0008649 [rRNA methyltransferase activity]
GO:0031167 [rRNA methylation]
GO:0031428 [box C/D snoRNP complex]
GO:0032040 [small-subunit processome]
Show all
 37 aa
3.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.