Expression of NUMBL in cancer - Summary - The Human Protein Atlas

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NUMBL

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NUMBL
Gene description	Numb homolog (Drosophila)-like
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Low cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA058251 , HPA058380
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), ovarian cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Ovarian cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA058251	HPA058380

GENE INFORMATION
Gene name	NUMBL (HGNC Symbol)
Synonyms	CAG3A, CTG3a, NUMB-R, NUMBLIKE, NUMBR, TNRC23
Description	Numb homolog (Drosophila)-like (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	40665905 - 40690972
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105245 (version 83.38)
Entrez gene	9253
UniProt	Q9Y6R0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y6R0
Antibodypedia	NUMBL antibodies

PROTEIN BROWSER

NUMBL-001	NUMBL-002	NUMBL-003	NUMBL-007	NUMBL-008	NUMBL-009	NUMBL-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NUMBL-001 ENSP00000252891 ENST00000252891	Q9Y6R0 [Direct mapping] Numb-like protein Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] GO:0007405 [neuroblast proliferation] GO:0007409 [axonogenesis] GO:0019221 [cytokine-mediated signaling pathway] GO:0019538 [protein metabolic process] GO:0021670 [lateral ventricle development] GO:0021849 [neuroblast division in subventricular zone] GO:0030900 [forebrain development] GO:0034332 [adherens junction organization] GO:0050769 [positive regulation of neurogenesis] GO:0050775 [positive regulation of dendrite morphogenesis] Show all	609 aa 64.9 kDa	No	0
NUMBL-002 ENSP00000472400 ENST00000598779	A0A0C4DGH3 [Direct mapping] Numb-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	568 aa 60.8 kDa	No	0
NUMBL-003 ENSP00000442759 ENST00000540131	A0A0C4DGH3 [Direct mapping] Numb-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	568 aa 60.8 kDa	No	0
NUMBL-007 ENSP00000471376 ENST00000600636	M0R0Q4 [Direct mapping] Numb-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	110 aa 12.6 kDa	No	0
NUMBL-008 ENSP00000469736 ENST00000598773	M0QYC2 [Direct mapping] Numb-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	235 aa 25.8 kDa	No	0
NUMBL-009 ENSP00000470794 ENST00000595741	M0QZV7 [Direct mapping] Numb-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	115 aa 13.1 kDa	No	0
NUMBL-010 ENSP00000469310 ENST00000600967	M0QXQ4 [Direct mapping] Numb-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	214 aa 22.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.