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Testicular and urothelial cancers along with several gastric cancers, pancreatic, liver, colorectal, cervical and breast cancers showed weak to moderate cytoplasmic and/or nuclear staining. Remaining cancer tissues were in general negative.
GENE INFORMATION
Gene name
POLR2I (HGNC Symbol)
Synonyms
hRPB14.5, RPB9
Description
Polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa (HGNC Symbol)
Entrez gene summary
This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]