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PRKD2

GENERAL INFORMATION

Gene name

 PRKD2

Gene description

 Protein kinase D2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues with high expression in lymphoid tissues. Membranous expression in a few tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA021490
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable).
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021490

GENE INFORMATION

Gene name

 PRKD2 (HGNC Symbol)

Synonyms

 DKFZP586E0820, HSPC187, PKD2

Description

 Protein kinase D2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 46674275 - 46717127

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105287 (version 83.38)

Entrez gene

 25865

UniProt

 Q9BZL6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZL6

Antibodypedia

 PRKD2 antibodies

PROTEIN BROWSER
PRKD2-001
PRKD2-002
PRKD2-004
PRKD2-006
PRKD2-010
PRKD2-011
PRKD2-013
PRKD2-015
PRKD2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRKD2-001
ENSP00000291281
ENST00000291281
Q9BZL6 [Direct mapping]
Serine/threonine-protein kinase D2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0008219 [cell death]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0061154 [endothelial tube morphogenesis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0089700 [protein kinase D signaling]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
 878 aa
96.7 kDa 		No 0
PRKD2-002
ENSP00000469106
ENST00000601806
Q9BZL6 [Direct mapping]
Serine/threonine-protein kinase D2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0008219 [cell death]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0061154 [endothelial tube morphogenesis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0089700 [protein kinase D signaling]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
 721 aa
80.1 kDa 		No 0
PRKD2-004
ENSP00000470804
ENST00000595515
B4DTS2 [Direct mapping]
Serine/threonine-protein kinase
Show all
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0046872 [metal ion binding]
Show all
 888 aa
97.7 kDa 		No 0
PRKD2-006
ENSP00000472744
ENST00000600194
Q9BZL6 [Direct mapping]
Serine/threonine-protein kinase D2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0008219 [cell death]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0061154 [endothelial tube morphogenesis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0089700 [protein kinase D signaling]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
 721 aa
80.1 kDa 		No 0
PRKD2-010
ENSP00000472987
ENST00000593363
M0R346 [Direct mapping]
Serine/threonine-protein kinase D2
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004697 [protein kinase C activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 69 aa
6.8 kDa 		No 0
PRKD2-011
ENSP00000470919
ENST00000598633
M0R012 [Direct mapping]
Serine/threonine-protein kinase D2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 18 aa
1.9 kDa 		No 0
PRKD2-013
ENSP00000470363
ENST00000595132
M0QZ82 [Direct mapping]
Serine/threonine-protein kinase D2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004697 [protein kinase C activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
Show all
 67 aa
7.2 kDa 		No 0
PRKD2-015
ENSP00000470442
ENST00000601605
M0QZC2 [Direct mapping]
Serine/threonine-protein kinase D2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004697 [protein kinase C activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0035556 [intracellular signal transduction]
Show all
 94 aa
10 kDa 		No 0
PRKD2-201
ENSP00000393978
ENST00000433867
Q9BZL6 [Direct mapping]
Serine/threonine-protein kinase D2
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0001938 [positive regulation of endothelial cell proliferation]
GO:0002250 [adaptive immune response]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004697 [protein kinase C activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007155 [cell adhesion]
GO:0008219 [cell death]
GO:0010595 [positive regulation of endothelial cell migration]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035924 [cellular response to vascular endothelial growth factor stimulus]
GO:0038033 [positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway]
GO:0043536 [positive regulation of blood vessel endothelial cell migration]
GO:0045743 [positive regulation of fibroblast growth factor receptor signaling pathway]
GO:0045766 [positive regulation of angiogenesis]
GO:0045785 [positive regulation of cell adhesion]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0050852 [T cell receptor signaling pathway]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0061154 [endothelial tube morphogenesis]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0089700 [protein kinase D signaling]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
GO:1901727 [positive regulation of histone deacetylase activity]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2001028 [positive regulation of endothelial cell chemotaxis]
Show all
 878 aa
96.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.