Tissue expression of DENND3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DENND3
Gene description	DENN/MADD domain containing 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DENND3 (HGNC Symbol)
Synonyms	KIAA0870
Description	DENN/MADD domain containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	141117278 - 141195808
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105339 (version 83.38)
Entrez gene	22898
UniProt	A2RUS2 (UniProt - Evidence at protein level)
neXtProt	NX_A2RUS2
Antibodypedia	DENND3 antibodies

PROTEIN BROWSER

DENND3-001	DENND3-002	DENND3-007	DENND3-010	DENND3-011	DENND3-012	DENND3-014	DENND3-015	DENND3-016	DENND3-021	DENND3-201	DENND3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DENND3-001 ENSP00000428714 ENST00000519811	E9PF32 [Direct mapping] DENN domain-containing protein 3 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1278 aa 144.3 kDa	No	0
DENND3-002 ENSP00000428276 ENST00000518668	H0YAY3 [Direct mapping] DENN domain-containing protein 3 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	1203 aa 135.9 kDa	No	0
DENND3-007 ENSP00000430912 ENST00000523308	B3KRG7 [Direct mapping] DENN domain-containing protein 3; DENN/MADD domain containing 3, isoform CRA_d; cDNA FLJ34237 fis, clone FCBBF3027328 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	248 aa 27.7 kDa	No	0
DENND3-010 ENSP00000430625 ENST00000519291	E5RJ42 [Direct mapping] DENN domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		125 aa 13.8 kDa	No	0
DENND3-011 ENSP00000430695 ENST00000518347	E5RIR7 [Direct mapping] DENN domain-containing protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		208 aa 22.9 kDa	No	0
DENND3-012 ENSP00000429780 ENST00000520986	E5RHH2 [Direct mapping] DENN domain-containing protein 3 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		280 aa 31.2 kDa	No	0
DENND3-014 ENSP00000429725 ENST00000520725	H0YBK9 [Direct mapping] DENN domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		170 aa 18.8 kDa	No	0
DENND3-015 ENSP00000429533 ENST00000517985	H0YBH5 [Direct mapping] DENN domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		122 aa 13.3 kDa	No	0
DENND3-016 ENSP00000428155 ENST00000518249	H0YAW2 [Direct mapping] DENN domain-containing protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		102 aa 11.8 kDa	No	0
DENND3-021 ENSP00000430786 ENST00000523058	E5RI43 [Direct mapping] DENN domain-containing protein 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		291 aa 32 kDa	No	0
DENND3-201 ENSP00000262585 ENST00000262585	A2RUS2 [Direct mapping] DENN domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0008333 [endosome to lysosome transport] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0043547 [positive regulation of GTPase activity] GO:0044257 [cellular protein catabolic process] Show all	1198 aa 135.9 kDa	No	1
DENND3-202 ENSP00000410594 ENST00000424248	A2RUS2 [Direct mapping] DENN domain-containing protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008333 [endosome to lysosome transport] GO:0017112 [Rab guanyl-nucleotide exchange factor activity] GO:0043547 [positive regulation of GTPase activity] GO:0044257 [cellular protein catabolic process] Show all	1146 aa 129.8 kDa	No	1