Expression of CD33 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CD33
Gene description	CD33 molecule
Protein class	CD markers FDA approved drug targets Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL, HL-60, HMC-1, U-937)
HPA (normal tissue):	Tissue enhanced (spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in subsets of lymphoid and hemaotpoietic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA035832 , CAB011442
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA035832	CAB011442

GENE INFORMATION
Gene name	CD33 (HGNC Symbol)
Synonyms	FLJ00391, p67, SIGLEC-3, SIGLEC3
Description	CD33 molecule (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	51225064 - 51243860
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105383 (version 83.38)
Entrez gene	945
UniProt	P20138 (UniProt - Evidence at protein level)
neXtProt	NX_P20138
Antibodypedia	CD33 antibodies

PROTEIN BROWSER

CD33-001	CD33-002	CD33-003	CD33-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD33-001 ENSP00000262262 ENST00000262262	P20138 [Direct mapping] Myeloid cell surface antigen CD33 Q546G0 [Target identity:100%; Query identity:100%] CD33 antigen (Gp67); CD33 antigen (Gp67), isoform CRA_b Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008285 [negative regulation of cell proliferation] GO:0009897 [external side of plasma membrane] GO:0030246 [carbohydrate binding] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	364 aa 39.8 kDa	Yes	1
CD33-002 ENSP00000410126 ENST00000421133	P20138 [Direct mapping] Myeloid cell surface antigen CD33 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008285 [negative regulation of cell proliferation] GO:0009897 [external side of plasma membrane] GO:0030246 [carbohydrate binding] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	237 aa 25.3 kDa	Yes	1
CD33-003 ENSP00000375673 ENST00000391796	P20138 [Direct mapping] Myeloid cell surface antigen CD33 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008285 [negative regulation of cell proliferation] GO:0009897 [external side of plasma membrane] GO:0030246 [carbohydrate binding] GO:0050776 [regulation of immune response] GO:0070062 [extracellular exosome] Show all	310 aa 33.9 kDa	Yes	1
CD33-005 ENSP00000403331 ENST00000436584	B4DF51 [Direct mapping] Myeloid cell surface antigen CD33; cDNA FLJ50122, highly similar to Myeloid cell surface antigen CD33 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	212 aa 22.3 kDa	Yes	1