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TYK2

GENERAL INFORMATION

Gene name

 TYK2

Gene description

 Tyrosine kinase 2

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membrane expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA005157
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable), pancreatic cancer (favourable), urothelial cancer (favourable), renal cancer (unfavourable) and endometrial cancer (favourable).
Head and neck cancer p<0.001
Pancreatic cancer p<0.001
Urothelial cancer p<0.001
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005157

GENE INFORMATION

Gene name

 TYK2 (HGNC Symbol)

Synonyms

 JTK1

Description

 Tyrosine kinase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.2

Chromosome location (bp)

 10350529 - 10380676

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105397 (version 83.38)

Entrez gene

 7297

UniProt

 P29597 (UniProt - Evidence at protein level)

neXtProt

 NX_P29597

Antibodypedia

 TYK2 antibodies

PROTEIN BROWSER
«
TYK2-001
TYK2-002
TYK2-003
TYK2-006
TYK2-007
TYK2-008
TYK2-011
TYK2-015
TYK2-018
TYK2-019
TYK2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TYK2-001
ENSP00000431885
ENST00000525621
P29597 [Direct mapping]
Non-receptor tyrosine-protein kinase TYK2
A0A024R7E4 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005131 [growth hormone receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031702 [type 1 angiotensin receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 1187 aa
133.6 kDa 		No 0
TYK2-002
ENSP00000432728
ENST00000529370
E9PPF2 [Direct mapping]
Non-receptor tyrosine-protein kinase TYK2
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
Show all
 921 aa
101.9 kDa 		No 0
TYK2-003
ENSP00000433203
ENST00000524462
E9PM19 [Direct mapping]
Tyrosine-protein kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
Show all
 1002 aa
113 kDa 		No 0
TYK2-006
ENSP00000436175
ENST00000531836
E9PQL2 [Direct mapping]
Non-receptor tyrosine-protein kinase TYK2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
Show all
 118 aa
13.2 kDa 		No 0
TYK2-007
ENSP00000467288
ENST00000525824
K7EP98 [Direct mapping]
Non-receptor tyrosine-protein kinase TYK2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
Show all
 104 aa
11.8 kDa 		No 0
TYK2-008
ENSP00000436826
ENST00000530829
E9PQE9 [Direct mapping]
Non-receptor tyrosine-protein kinase TYK2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
Show all
 134 aa
14.7 kDa 		No 0
TYK2-011
ENSP00000434931
ENST00000525220
H0YE41 [Direct mapping]
Non-receptor tyrosine-protein kinase TYK2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
Show all
 195 aa
21.9 kDa 		No 0
TYK2-015
ENSP00000434831
ENST00000525976
H0YE24 [Direct mapping]
Non-receptor tyrosine-protein kinase TYK2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
Show all
 64 aa
7.2 kDa 		No 0
TYK2-018
ENSP00000436155
ENST00000529739
E9PQM4 [Direct mapping]
Non-receptor tyrosine-protein kinase TYK2
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
Show all
 129 aa
14.9 kDa 		No 0
TYK2-019
ENSP00000465291
ENST00000530560
K7EJR6 [Direct mapping]
Non-receptor tyrosine-protein kinase TYK2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016477 [cell migration]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
Show all
 142 aa
16 kDa 		No 0
TYK2-201
ENSP00000264818
ENST00000264818
P29597 [Direct mapping]
Non-receptor tyrosine-protein kinase TYK2
A0A024R7E4 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005131 [growth hormone receptor binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030154 [cell differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0042127 [regulation of cell proliferation]
GO:0045087 [innate immune response]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0070062 [extracellular exosome]
Show all
 1187 aa
133.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.