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ATP1A3

GENERAL INFORMATION

Gene name

 ATP1A3

Gene description

 ATPase, Na+/K+ transporting, alpha 3 polypeptide

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, testis cancer)
HPA (cell line):Cell line enhanced (SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (cerebral cortex, heart muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct expression in brain and cardiac myocytes.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA045367 , HPA056446 , CAB033630
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), pancreatic cancer (favourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA045367
HPA056446
CAB033630

GENE INFORMATION

Gene name

 ATP1A3 (HGNC Symbol)

Synonyms

 DYT12

Description

 ATPase, Na+/K+ transporting, alpha 3 polypeptide (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 19

Cytoband

 q13.2

Chromosome location (bp)

 41966582 - 41997497

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105409 (version 83.38)

Entrez gene

 478

UniProt

 P13637 (UniProt - Evidence at protein level)

neXtProt

 NX_P13637

Antibodypedia

 ATP1A3 antibodies

PROTEIN BROWSER
ATP1A3-001
ATP1A3-005
ATP1A3-007
ATP1A3-008
ATP1A3-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATP1A3-001
ENSP00000302397
ENST00000302102
P13637 [Direct mapping]
Sodium/potassium-transporting ATPase subunit alpha-3
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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0008152 [metabolic process]
GO:0010107 [potassium ion import]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0030007 [cellular potassium ion homeostasis]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0051087 [chaperone binding]
GO:0055085 [transmembrane transport]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:1903416 [response to glycoside]
GO:1903561 [extracellular vesicle]
GO:1990239 [steroid hormone binding]
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 1013 aa
111.7 kDa 		No >9
ATP1A3-005
ENSP00000471581
ENST00000602133
M0R116 [Direct mapping]
Sodium/potassium-transporting ATPase subunit alpha-3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005524 [ATP binding]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0046872 [metal ion binding]
Show all
 983 aa
108.3 kDa 		No >9
ATP1A3-007
ENSP00000437577
ENST00000543770
P13637 [Direct mapping]
Sodium/potassium-transporting ATPase subunit alpha-3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005524 [ATP binding]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0008152 [metabolic process]
GO:0010107 [potassium ion import]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0030007 [cellular potassium ion homeostasis]
GO:0034220 [ion transmembrane transport]
GO:0036376 [sodium ion export from cell]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0051087 [chaperone binding]
GO:0055085 [transmembrane transport]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:1903416 [response to glycoside]
GO:1903561 [extracellular vesicle]
GO:1990239 [steroid hormone binding]
Show all
 1024 aa
113.1 kDa 		No >9
ATP1A3-008
ENSP00000444688
ENST00000545399
P13637 [Direct mapping]
Sodium/potassium-transporting ATPase subunit alpha-3
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005391 [sodium:potassium-exchanging ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005794 [Golgi apparatus]
GO:0005886 [plasma membrane]
GO:0005890 [sodium:potassium-exchanging ATPase complex]
GO:0006813 [potassium ion transport]
GO:0006814 [sodium ion transport]
GO:0006883 [cellular sodium ion homeostasis]
GO:0007613 [memory]
GO:0008152 [metabolic process]
GO:0008344 [adult locomotory behavior]
GO:0008542 [visual learning]
GO:0010107 [potassium ion import]
GO:0015991 [ATP hydrolysis coupled proton transport]
GO:0016021 [integral component of membrane]
GO:0030007 [cellular potassium ion homeostasis]
GO:0030424 [axon]
GO:0031748 [D1 dopamine receptor binding]
GO:0034220 [ion transmembrane transport]
GO:0035235 [ionotropic glutamate receptor signaling pathway]
GO:0036376 [sodium ion export from cell]
GO:0042383 [sarcolemma]
GO:0042493 [response to drug]
GO:0043209 [myelin sheath]
GO:0043395 [heparan sulfate proteoglycan binding]
GO:0044326 [dendritic spine neck]
GO:0044327 [dendritic spine head]
GO:0045202 [synapse]
GO:0046872 [metal ion binding]
GO:0051087 [chaperone binding]
GO:0055085 [transmembrane transport]
GO:0060048 [cardiac muscle contraction]
GO:0071383 [cellular response to steroid hormone stimulus]
GO:0086036 [regulation of cardiac muscle cell membrane potential]
GO:0086037 [sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential]
GO:0086064 [cell communication by electrical coupling involved in cardiac conduction]
GO:1903416 [response to glycoside]
GO:1903561 [extracellular vesicle]
GO:1990239 [steroid hormone binding]
Show all
 1026 aa
113.1 kDa 		No >9
ATP1A3-011
ENSP00000469129
ENST00000473086
M0QXF2 [Direct mapping]
Sodium/potassium-transporting ATPase subunit alpha-3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016787 [hydrolase activity]
GO:0046872 [metal ion binding]
Show all
 251 aa
27.3 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.