Fields »
ABOUT
HELP
BLOG
LIG1

GENERAL INFORMATION

Gene name

 LIG1

Gene description

 Ligase I, DNA, ATP-dependent

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 2 antibodies.
HPA041431 , CAB037015
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041431
CAB037015

GENE INFORMATION

Gene name

 LIG1

Synonyms

Description

 Ligase I, DNA, ATP-dependent (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 48115445 - 48170603

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105486 (version 83.38)

Entrez gene

 3978

UniProt

 P18858 (UniProt - Evidence at protein level)

neXtProt

 NX_P18858

Antibodypedia

 LIG1 antibodies

PROTEIN BROWSER
LIG1-001
LIG1-002
LIG1-008
LIG1-009
LIG1-014
LIG1-201
LIG1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LIG1-001
ENSP00000263274
ENST00000263274
P18858 [Direct mapping]
DNA ligase 1
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006259 [DNA metabolic process]
GO:0006260 [DNA replication]
GO:0006266 [DNA ligation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006273 [lagging strand elongation]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006310 [DNA recombination]
GO:0009653 [anatomical structure morphogenesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0042542 [response to hydrogen peroxide]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051301 [cell division]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071897 [DNA biosynthetic process]
GO:1903461 [Okazaki fragment processing involved in mitotic DNA replication]
GO:1903469 [removal of RNA primer involved in mitotic DNA replication]
Show all
 919 aa
101.7 kDa 		No 0
LIG1-002
ENSP00000442841
ENST00000427526
P18858 [Direct mapping]
DNA ligase 1
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006259 [DNA metabolic process]
GO:0006266 [DNA ligation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006273 [lagging strand elongation]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0006310 [DNA recombination]
GO:0009653 [anatomical structure morphogenesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051301 [cell division]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071897 [DNA biosynthetic process]
GO:1903461 [Okazaki fragment processing involved in mitotic DNA replication]
GO:1903469 [removal of RNA primer involved in mitotic DNA replication]
Show all
 888 aa
98.2 kDa 		No 0
LIG1-008
ENSP00000472085
ENST00000598938
M0R1S4 [Direct mapping]
DNA ligase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003910 [DNA ligase (ATP) activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006266 [DNA ligation]
GO:0006273 [lagging strand elongation]
GO:1903461 [Okazaki fragment processing involved in mitotic DNA replication]
GO:1903469 [removal of RNA primer involved in mitotic DNA replication]
Show all
 28 aa
3.2 kDa 		No 0
LIG1-009
ENSP00000469638
ENST00000593425
M0QY71 [Direct mapping]
DNA ligase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003910 [DNA ligase (ATP) activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006266 [DNA ligation]
GO:0006273 [lagging strand elongation]
GO:1903461 [Okazaki fragment processing involved in mitotic DNA replication]
GO:1903469 [removal of RNA primer involved in mitotic DNA replication]
Show all
 145 aa
15.8 kDa 		No 0
LIG1-014
ENSP00000471861
ENST00000596549
M0R1G7 [Direct mapping]
DNA ligase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003910 [DNA ligase (ATP) activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006266 [DNA ligation]
GO:0006273 [lagging strand elongation]
GO:1903461 [Okazaki fragment processing involved in mitotic DNA replication]
GO:1903469 [removal of RNA primer involved in mitotic DNA replication]
Show all
 150 aa
16.3 kDa 		No 0
LIG1-201
ENSP00000441531
ENST00000536218
F5GZ28 [Direct mapping]
DNA ligase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006266 [DNA ligation]
GO:0006273 [lagging strand elongation]
GO:0006281 [DNA repair]
GO:0006310 [DNA recombination]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0071897 [DNA biosynthetic process]
GO:1903461 [Okazaki fragment processing involved in mitotic DNA replication]
GO:1903469 [removal of RNA primer involved in mitotic DNA replication]
Show all
 851 aa
93.9 kDa 		No 0
LIG1-202
ENSP00000483027
ENST00000613670
P18858 [Direct mapping]
DNA ligase 1
Show all
Enzymes
   ENZYME proteins
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000722 [telomere maintenance via recombination]
GO:0000723 [telomere maintenance]
GO:0003677 [DNA binding]
GO:0003909 [DNA ligase activity]
GO:0003910 [DNA ligase (ATP) activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005794 [Golgi apparatus]
GO:0006259 [DNA metabolic process]
GO:0006266 [DNA ligation]
GO:0006271 [DNA strand elongation involved in DNA replication]
GO:0006273 [lagging strand elongation]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006297 [nucleotide-excision repair, DNA gap filling]
GO:0006298 [mismatch repair]
GO:0006310 [DNA recombination]
GO:0009653 [anatomical structure morphogenesis]
GO:0032201 [telomere maintenance via semi-conservative replication]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046872 [metal ion binding]
GO:0051103 [DNA ligation involved in DNA repair]
GO:0051301 [cell division]
GO:0070911 [global genome nucleotide-excision repair]
GO:0071897 [DNA biosynthetic process]
GO:1903461 [Okazaki fragment processing involved in mitotic DNA replication]
GO:1903469 [removal of RNA primer involved in mitotic DNA replication]
Show all
 801 aa
88.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.