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SIGLEC6

GENERAL INFORMATION

Gene name

 SIGLEC6

Gene description

 Sialic acid binding Ig-like lectin 6

Protein class

 CD markers
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (thyroid cancer)
HPA (cell line):Cell line enriched (HMC-1)
HPA (normal tissue):Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in placental trophoblasts.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA009084 , HPA018198
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA009084
HPA018198

GENE INFORMATION

Gene name

 SIGLEC6 (HGNC Symbol)

Synonyms

 CD327, CD33L, CD33L1, OB-BP1, SIGLEC-6

Description

 Sialic acid binding Ig-like lectin 6 (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 q13.41

Chromosome location (bp)

 51519525 - 51531856

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105492 (version 83.38)

Entrez gene

 946

UniProt

 O43699 (UniProt - Evidence at protein level)

neXtProt

 NX_O43699

Antibodypedia

 SIGLEC6 antibodies

PROTEIN BROWSER
SIGLEC6-001
SIGLEC6-002
SIGLEC6-003
SIGLEC6-005
SIGLEC6-007
SIGLEC6-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIGLEC6-001
ENSP00000401502
ENST00000425629
O43699 [Direct mapping]
Sialic acid-binding Ig-like lectin 6
A0A024R4K4 [Target identity:100%; Query identity:100%]
Sialic acid binding Ig-like lectin 6, isoform CRA_a
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007267 [cell-cell signaling]
GO:0016020 [membrane]
GO:0030246 [carbohydrate binding]
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 453 aa
49.9 kDa 		Yes 1
SIGLEC6-002
ENSP00000344064
ENST00000346477
O43699 [Direct mapping]
Sialic acid-binding Ig-like lectin 6
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007267 [cell-cell signaling]
GO:0016020 [membrane]
GO:0030246 [carbohydrate binding]
Show all
 437 aa
48.3 kDa 		Yes 1
SIGLEC6-003
ENSP00000345907
ENST00000343300
O43699 [Direct mapping]
Sialic acid-binding Ig-like lectin 6
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CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007267 [cell-cell signaling]
GO:0016020 [membrane]
GO:0030246 [carbohydrate binding]
Show all
 353 aa
38.8 kDa 		Yes 0
SIGLEC6-005
ENSP00000353071
ENST00000359982
O43699 [Direct mapping]
Sialic acid-binding Ig-like lectin 6
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007267 [cell-cell signaling]
GO:0016020 [membrane]
GO:0030246 [carbohydrate binding]
Show all
 389 aa
42.6 kDa 		Yes 1
SIGLEC6-007
ENSP00000410679
ENST00000436458
O43699 [Direct mapping]
Sialic acid-binding Ig-like lectin 6
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007267 [cell-cell signaling]
GO:0016020 [membrane]
GO:0030246 [carbohydrate binding]
Show all
 401 aa
44.3 kDa 		No 1
SIGLEC6-008
ENSP00000375674
ENST00000391797
O43699 [Direct mapping]
Sialic acid-binding Ig-like lectin 6
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CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007267 [cell-cell signaling]
GO:0016020 [membrane]
GO:0030246 [carbohydrate binding]
Show all
 342 aa
37.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.