Cell atlas - PLA2G4C - The Human Protein Atlas

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PLA2G4C

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	PLA2G4C
Gene description	Phospholipase A2, group IVC (cytosolic, calcium-independent)
Protein class	Enzymes Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (TIME)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA043083
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (TIME) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA043083	RH-30	Cytosol
	HPA043083	U-2 OS	Cytosol
	HPA043083	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PLA2G4C (HGNC Symbol)
Synonyms	cPLA2-gamma
Description	Phospholipase A2, group IVC (cytosolic, calcium-independent) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein which is a member of the phospholipase A2 enzyme family which hydrolyzes glycerophospholipids to produce free fatty acids and lysophospholipids, both of which serve as precursors in the production of signaling molecules. The encoded protein has been shown to be a calcium-independent and membrane bound enzyme. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48047843 - 48110817
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105499 (version 83.38)
Entrez gene	8605
UniProt	Q9UP65 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UP65
Antibodypedia	PLA2G4C antibodies

PROTEIN BROWSER

PLA2G4C-001	PLA2G4C-004	PLA2G4C-005	PLA2G4C-009	PLA2G4C-010	PLA2G4C-017	PLA2G4C-020	PLA2G4C-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLA2G4C-001 ENSP00000472546 ENST00000599111	Q9UP65 [Direct mapping] Cytosolic phospholipase A2 gamma Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0004620 [phospholipase activity] GO:0005543 [phospholipid binding] GO:0005635 [nuclear envelope] GO:0005654 [nucleoplasm] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0005938 [cell cortex] GO:0006644 [phospholipid metabolic process] GO:0006954 [inflammatory response] GO:0007567 [parturition] GO:0008152 [metabolic process] GO:0009395 [phospholipid catabolic process] GO:0016020 [membrane] GO:0019369 [arachidonic acid metabolic process] GO:0035556 [intracellular signal transduction] GO:0036149 [phosphatidylinositol acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0046475 [glycerophospholipid catabolic process] GO:0047499 [calcium-independent phospholipase A2 activity] Show all	551 aa 62.5 kDa	No	0
PLA2G4C-004 ENSP00000469473 ENST00000599921	Q9UP65 [Direct mapping] Cytosolic phospholipase A2 gamma A0A024QZH0 [Target identity:100%; Query identity:100%] Phospholipase A2, group IVC (Cytosolic, calcium-independent), isoform CRA_d Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0004620 [phospholipase activity] GO:0005543 [phospholipid binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006954 [inflammatory response] GO:0007567 [parturition] GO:0008152 [metabolic process] GO:0009395 [phospholipid catabolic process] GO:0016020 [membrane] GO:0019369 [arachidonic acid metabolic process] GO:0035556 [intracellular signal transduction] GO:0036149 [phosphatidylinositol acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0046475 [glycerophospholipid catabolic process] GO:0047499 [calcium-independent phospholipase A2 activity] Show all	541 aa 60.9 kDa	No	0
PLA2G4C-005 ENSP00000346228 ENST00000354276	Q9UP65 [Direct mapping] Cytosolic phospholipase A2 gamma Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Show all	GO:0004620 [phospholipase activity] GO:0005543 [phospholipid binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006954 [inflammatory response] GO:0007567 [parturition] GO:0008152 [metabolic process] GO:0009395 [phospholipid catabolic process] GO:0016020 [membrane] GO:0019369 [arachidonic acid metabolic process] GO:0035556 [intracellular signal transduction] GO:0036149 [phosphatidylinositol acyl-chain remodeling] GO:0036151 [phosphatidylcholine acyl-chain remodeling] GO:0036152 [phosphatidylethanolamine acyl-chain remodeling] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] GO:0046475 [glycerophospholipid catabolic process] GO:0047499 [calcium-independent phospholipase A2 activity] Show all	527 aa 59.4 kDa	No	0
PLA2G4C-009 ENSP00000471196 ENST00000596138	M0R0F6 [Direct mapping] Cytosolic phospholipase A2 gamma Show all	Predicted intracellular proteins RAS pathway related proteins Show all		39 aa 4.4 kDa	No	0
PLA2G4C-010 ENSP00000471759 ENST00000596352	M0R1B4 [Direct mapping] Cytosolic phospholipase A2 gamma Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0004620 [phospholipase activity] GO:0008152 [metabolic process] GO:0009395 [phospholipid catabolic process] Show all	47 aa 5.2 kDa	No	0
PLA2G4C-017 ENSP00000472977 ENST00000601946	M0R339 [Direct mapping] Cytosolic phospholipase A2 gamma Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0004620 [phospholipase activity] GO:0008152 [metabolic process] GO:0009395 [phospholipid catabolic process] Show all	194 aa 22.4 kDa	No	0
PLA2G4C-020 ENSP00000470418 ENST00000599300	M0QZB1 [Direct mapping] Cytosolic phospholipase A2 gamma Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0004620 [phospholipase activity] GO:0008152 [metabolic process] GO:0009395 [phospholipid catabolic process] Show all	214 aa 24.3 kDa	No	0
PLA2G4C-024 ENSP00000469528 ENST00000595161	M0QY18 [Direct mapping] Cytosolic phospholipase A2 gamma Show all	Predicted intracellular proteins RAS pathway related proteins Show all	GO:0008152 [metabolic process] Show all	130 aa 14.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.