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DBP

GENERAL INFORMATION

Gene name

 DBP

Gene description

 D site of albumin promoter (albumin D-box) binding protein

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (NB-4)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable), renal cancer (favourable) and head and neck cancer (favourable).
Lung cancer p<0.001
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DBP (HGNC Symbol)

Synonyms

 DABP

Description

 D site of albumin promoter (albumin D-box) binding protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 48630030 - 48637438

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105516 (version 83.38)

Entrez gene

 1628

UniProt

 Q10586 (UniProt - Evidence at protein level)

neXtProt

 NX_Q10586

Antibodypedia

 DBP antibodies

PROTEIN BROWSER
DBP-001
DBP-002
DBP-004
DBP-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DBP-001
ENSP00000222122
ENST00000222122
Q10586 [Direct mapping]
D site-binding protein
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Predicted intracellular proteins
Transcription factors
   Basic domains
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001889 [liver development]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
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 325 aa
34.3 kDa 		No 0
DBP-002
ENSP00000469291
ENST00000601104
M0QXP1 [Direct mapping]
D site-binding protein
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Predicted intracellular proteins
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
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 262 aa
26.7 kDa 		No 0
DBP-004
ENSP00000469426
ENST00000599385
M0QXW3 [Direct mapping]
D site-binding protein
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Predicted intracellular proteins
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0043565 [sequence-specific DNA binding]
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 123 aa
14.5 kDa 		No 0
DBP-005
ENSP00000471220
ENST00000593500
M0QXW3 [Direct mapping]
D site-binding protein
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Predicted intracellular proteins
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0043565 [sequence-specific DNA binding]
Show all
 123 aa
14.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.