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FGF21

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GENERAL INFORMATION

Gene name

 FGF21

Gene description

 Fibroblast growth factor 21

Protein class

 Predicted secreted proteins
RAS pathway related proteins

Predicted localization

 Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enriched (U-2 OS)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enriched (U-2 OS)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 FGF21

Synonyms

Description

 Fibroblast growth factor 21 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 48755559 - 48758330

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105550 (version 83.38)

Entrez gene

 26291

UniProt

 Q9NSA1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NSA1

Antibodypedia

 FGF21 antibodies

PROTEIN BROWSER
FGF21-001
FGF21-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FGF21-001
ENSP00000471477
ENST00000593756
Q9NSA1 [Direct mapping]
Fibroblast growth factor 21
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008083 [growth factor activity]
GO:0008284 [positive regulation of cell proliferation]
GO:0010988 [regulation of low-density lipoprotein particle clearance]
GO:0014823 [response to activity]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031667 [response to nutrient levels]
GO:0035690 [cellular response to drug]
GO:0045716 [positive regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071333 [cellular response to glucose stimulus]
GO:0071404 [cellular response to low-density lipoprotein particle stimulus]
GO:0072577 [endothelial cell apoptotic process]
GO:0090080 [positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway]
GO:2000352 [negative regulation of endothelial cell apoptotic process]
Show all
 209 aa
22.3 kDa 		Yes 0
FGF21-201
ENSP00000222157
ENST00000222157
Q9NSA1 [Direct mapping]
Fibroblast growth factor 21
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
RAS pathway related proteins
Show all
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0007165 [signal transduction]
GO:0007267 [cell-cell signaling]
GO:0008083 [growth factor activity]
GO:0010988 [regulation of low-density lipoprotein particle clearance]
GO:0045716 [positive regulation of low-density lipoprotein particle receptor biosynthetic process]
GO:0046326 [positive regulation of glucose import]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
Show all
 209 aa
22.3 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.