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BCAT2

GENERAL INFORMATION

Gene name

 BCAT2

Gene description

 Branched chain amino-acid transaminase 2, mitochondrial

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA054091
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054091

GENE INFORMATION

Gene name

 BCAT2 (HGNC Symbol)

Synonyms

 BCAM, BCT2

Description

 Branched chain amino-acid transaminase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 This gene encodes a branched chain aminotransferase found in mitochondria. The encoded protein forms a dimer that catalyzes the first step in the production of the branched chain amino acids leucine, isoleucine, and valine. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 48795062 - 48811029

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105552 (version 83.38)

Entrez gene

 587

UniProt

 O15382 (UniProt - Evidence at protein level)

neXtProt

 NX_O15382

Antibodypedia

 BCAT2 antibodies

PROTEIN BROWSER
BCAT2-001
BCAT2-002
BCAT2-003
BCAT2-004
BCAT2-005
BCAT2-006
BCAT2-008
BCAT2-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BCAT2-001
ENSP00000322991
ENST00000316273
O15382 [Direct mapping]
Branched-chain-amino-acid aminotransferase, mitochondrial
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Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006549 [isoleucine metabolic process]
GO:0006550 [isoleucine catabolic process]
GO:0006551 [leucine metabolic process]
GO:0006573 [valine metabolic process]
GO:0008152 [metabolic process]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0010817 [regulation of hormone levels]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 392 aa
44.3 kDa 		No 0
BCAT2-002
ENSP00000470680
ENST00000599246
M0QZP4 [Direct mapping]
Branched-chain-amino-acid aminotransferase
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0008152 [metabolic process]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 313 aa
34.9 kDa 		No 0
BCAT2-003
ENSP00000385161
ENST00000402551
B3KSI3 [Direct mapping]
Branched-chain-amino-acid aminotransferase
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0008152 [metabolic process]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 352 aa
39.9 kDa 		No 0
BCAT2-004
ENSP00000470216
ENST00000598162
M0QZ10 [Direct mapping]
Branched-chain-amino-acid aminotransferase
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0008152 [metabolic process]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 405 aa
45.4 kDa 		No 0
BCAT2-005
ENSP00000472641
ENST00000601681
M0R2K7 [Direct mapping]
Branched-chain-amino-acid aminotransferase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0008152 [metabolic process]
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 109 aa
12.8 kDa 		No 0
BCAT2-006
ENSP00000469651
ENST00000597011
B3KSI3 [Direct mapping]
Branched-chain-amino-acid aminotransferase
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0008152 [metabolic process]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 352 aa
39.9 kDa 		No 0
BCAT2-008
ENSP00000469139
ENST00000593515
M0QXF9 [Direct mapping]
Branched-chain-amino-acid aminotransferase
Show all
   THUMBUP predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0008152 [metabolic process]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 445 aa
50 kDa 		No 0
BCAT2-012
ENSP00000440973
ENST00000545387
O15382 [Direct mapping]
Branched-chain-amino-acid aminotransferase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004084 [branched-chain-amino-acid transaminase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0008152 [metabolic process]
GO:0009081 [branched-chain amino acid metabolic process]
GO:0009082 [branched-chain amino acid biosynthetic process]
GO:0009083 [branched-chain amino acid catabolic process]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0052654 [L-leucine transaminase activity]
GO:0052655 [L-valine transaminase activity]
GO:0052656 [L-isoleucine transaminase activity]
Show all
 300 aa
33.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.