Expression of PLEKHA4 in cancer - Summary - The Human Protein Atlas

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PLEKHA4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PLEKHA4
Gene description	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AN3-CA, BJ hTERT+ SV40 Large T+ RasG12V, SK-MEL-30)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA042978 , HPA048473
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and liver cancer (unfavourable).
Breast cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042978	HPA048473

GENE INFORMATION
Gene name	PLEKHA4 (HGNC Symbol)
Synonyms	PEPP1
Description	Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	48837097 - 48868632
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105559 (version 83.38)
Entrez gene	57664
UniProt	Q9H4M7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H4M7
Antibodypedia	PLEKHA4 antibodies

PROTEIN BROWSER

PLEKHA4-001	PLEKHA4-002	PLEKHA4-005	PLEKHA4-006	PLEKHA4-009	PLEKHA4-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHA4-001 ENSP00000263265 ENST00000263265	Q9H4M7 [Direct mapping] Pleckstrin homology domain-containing family A member 4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005545 [1-phosphatidylinositol binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] GO:0016020 [membrane] Show all	779 aa 85.4 kDa	No	0
PLEKHA4-002 ENSP00000471274 ENST00000594100	M0R0J1 [Direct mapping] Pleckstrin homology domain-containing family A member 4 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		201 aa 21.8 kDa	No	0
PLEKHA4-005 ENSP00000469211 ENST00000595867	M0QXJ3 [Direct mapping] Pleckstrin homology domain-containing family A member 4 Show all	Predicted intracellular proteins Show all		59 aa 6.3 kDa	No	0
PLEKHA4-006 ENSP00000472636 ENST00000594195	M0R2K5 [Direct mapping] Pleckstrin homology domain-containing family A member 4 Show all	Predicted intracellular proteins Show all		127 aa 14.6 kDa	No	0
PLEKHA4-009 ENSP00000471462 ENST00000597129	M0R0V1 [Direct mapping] Pleckstrin homology domain-containing family A member 4 Show all	Predicted intracellular proteins Show all		119 aa 12.9 kDa	No	0
PLEKHA4-011 ENSP00000347683 ENST00000355496	Q9H4M7 [Direct mapping] Pleckstrin homology domain-containing family A member 4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005545 [1-phosphatidylinositol binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0008150 [biological_process] GO:0016020 [membrane] Show all	583 aa 64.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.