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GCDH

GENERAL INFORMATION

Gene name

 GCDH

Gene description

 Glutaryl-CoA dehydrogenase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA043252 , HPA048492
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (favourable) and lung cancer (favourable).
Renal cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA043252
HPA048492

GENE INFORMATION

Gene name

 GCDH (HGNC Symbol)

Synonyms

 ACAD5

Description

 Glutaryl-CoA dehydrogenase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the acyl-CoA dehydrogenase family. It catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. The enzyme exists in the mitochondrial matrix as a homotetramer of 45-kD subunits. Mutations in this gene result in the metabolic disorder glutaric aciduria type 1, which is also known as glutaric acidemia type I. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 12. [provided by RefSeq, Mar 2013]

Chromosome

 19

Cytoband

 p13.13

Chromosome location (bp)

 12891026 - 12914207

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105607 (version 83.38)

Entrez gene

 2639

UniProt

 Q92947 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92947

Antibodypedia

 GCDH antibodies

PROTEIN BROWSER
GCDH-001
GCDH-002
GCDH-008
GCDH-010
GCDH-012
GCDH-015
GCDH-016

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GCDH-001
ENSP00000222214
ENST00000222214
Q92947 [Direct mapping]
Glutaryl-CoA dehydrogenase, mitochondrial
A0A024R7F9 [Target identity:100%; Query identity:100%]
Glutaryl-Coenzyme A dehydrogenase, isoform CRA_a
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0004361 [glutaryl-CoA dehydrogenase activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005759 [mitochondrial matrix]
GO:0006554 [lysine catabolic process]
GO:0006568 [tryptophan metabolic process]
GO:0006637 [acyl-CoA metabolic process]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0019395 [fatty acid oxidation]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046949 [fatty-acyl-CoA biosynthetic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
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 438 aa
48.1 kDa 		No 0
GCDH-002
ENSP00000466845
ENST00000591470
Q92947 [Direct mapping]
Glutaryl-CoA dehydrogenase, mitochondrial
A0A024R7F9 [Target identity:100%; Query identity:100%]
Glutaryl-Coenzyme A dehydrogenase, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000062 [fatty-acyl-CoA binding]
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0004361 [glutaryl-CoA dehydrogenase activity]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006554 [lysine catabolic process]
GO:0006568 [tryptophan metabolic process]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0033539 [fatty acid beta-oxidation using acyl-CoA dehydrogenase]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0052890 [oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor]
GO:0055088 [lipid homeostasis]
GO:0055114 [oxidation-reduction process]
Show all
 438 aa
48.1 kDa 		No 0
GCDH-008
ENSP00000465618
ENST00000589039
K7EKH1 [Direct mapping]
Glutaryl-CoA dehydrogenase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 148 aa
16.7 kDa 		No 0
GCDH-010
ENSP00000465770
ENST00000588905
K7EKT3 [Direct mapping]
Glutaryl-CoA dehydrogenase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
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 164 aa
18.4 kDa 		No 0
GCDH-012
ENSP00000468625
ENST00000590472
K7ESA6 [Direct mapping]
Glutaryl-CoA dehydrogenase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
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 115 aa
12.6 kDa 		No 0
GCDH-015
ENSP00000468584
ENST00000587072
K7ES74 [Direct mapping]
Glutaryl-CoA dehydrogenase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0050660 [flavin adenine dinucleotide binding]
GO:0055114 [oxidation-reduction process]
Show all
 131 aa
14.5 kDa 		No 0
GCDH-016
ENSP00000467735
ENST00000591050
K7EQ99 [Direct mapping]
Glutaryl-CoA dehydrogenase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003995 [acyl-CoA dehydrogenase activity]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0055114 [oxidation-reduction process]
Show all
 102 aa
10.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.