Expression of KLF1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KLF1
Gene description	Kruppel-like factor 1 (erythroid)
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in hematopoietic cells in bone marrow and immune cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA051850
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

STAINING SUMMARY

HPA051850

GENE INFORMATION
Gene name	KLF1 (HGNC Symbol)
Synonyms	EKLF
Description	Kruppel-like factor 1 (erythroid) (HGNC Symbol)
Entrez gene summary	This gene encodes a hematopoietic-specific transcription factor that induces high-level expression of adult beta-globin and other erythroid genes. The zinc-finger protein binds to the DNA sequence CCACACCCT found in the beta hemoglobin promoter. Heterozygous loss-of-function mutations in this gene result in the dominant In(Lu) blood phenotype. [provided by RefSeq, Oct 2009]
Chromosome	19
Cytoband	p13.13
Chromosome location (bp)	12884423 - 12887181
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105610 (version 83.38)
Entrez gene	10661
UniProt	Q13351 (UniProt - Evidence at protein level)
neXtProt	NX_Q13351
Antibodypedia	KLF1 antibodies

PROTEIN BROWSER

KLF1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLF1-001 ENSP00000264834 ENST00000264834	Q13351 [Direct mapping] Krueppel-like factor 1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0000790 [nuclear chromatin] GO:0000987 [core promoter proximal region sequence-specific DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030218 [erythrocyte differentiation] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046872 [metal ion binding] GO:1901653 [cellular response to peptide] Show all	362 aa 38.2 kDa	No	0