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PRPF31

GENERAL INFORMATION

Gene name

 PRPF31

Gene description

 Pre-mRNA processing factor 31

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA041939
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041939

GENE INFORMATION

Gene name

 PRPF31 (HGNC Symbol)

Synonyms

 hPrp31, NY-BR-99, PRP31, RP11, SNRNP61

Description

 Pre-mRNA processing factor 31 (HGNC Symbol)

Entrez gene summary

 This gene encodes a component of the spliceosome complex and is one of several retinitis pigmentosa-causing genes. When the gene product is added to the spliceosome complex, activation occurs.[provided by RefSeq, Jan 2009]

Chromosome

 19

Cytoband

 q13.42

Chromosome location (bp)

 54115410 - 54131719

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105618 (version 83.38)

Entrez gene

 26121

UniProt

 Q8WWY3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WWY3

Antibodypedia

 PRPF31 antibodies

PROTEIN BROWSER
PRPF31-001
PRPF31-003
PRPF31-005
PRPF31-006
PRPF31-009
PRPF31-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PRPF31-001
ENSP00000324122
ENST00000321030
Q8WWY3 [Direct mapping]
U4/U6 small nuclear ribonucleoprotein Prp31
F1T0A5 [Target identity:100%; Query identity:100%]
PRP31 pre-mRNA processing factor 31 homolog (Yeast), isoform CRA_a; U4/U6 small nuclear ribonucleoprotein Prp31
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005684 [U2-type spliceosomal complex]
GO:0005687 [U4 snRNP]
GO:0005690 [U4atac snRNP]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0030621 [U4 snRNA binding]
GO:0030622 [U4atac snRNA binding]
GO:0043021 [ribonucleoprotein complex binding]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0070990 [snRNP binding]
GO:0071011 [precatalytic spliceosome]
GO:0071339 [MLL1 complex]
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 499 aa
55.5 kDa 		No 0
PRPF31-003
ENSP00000375635
ENST00000391755
E7EVX8 [Direct mapping]
U4/U6 small nuclear ribonucleoprotein Prp31
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 493 aa
54.8 kDa 		No 0
PRPF31-005
ENSP00000395894
ENST00000445811
E7EN72 [Direct mapping]
U4/U6 small nuclear ribonucleoprotein Prp31
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0005634 [nucleus]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
Show all
 284 aa
31.4 kDa 		No 0
PRPF31-006
ENSP00000408980
ENST00000445124
E7ESX0 [Direct mapping]
U4/U6 small nuclear ribonucleoprotein Prp31
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0005634 [nucleus]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
Show all
 276 aa
30.6 kDa 		No 0
PRPF31-009
ENSP00000395089
ENST00000447810
E7EU94 [Direct mapping]
U4/U6 small nuclear ribonucleoprotein Prp31
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0005634 [nucleus]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
Show all
 261 aa
28.9 kDa 		No 0
PRPF31-201
ENSP00000405166
ENST00000419967
Q8WWY3 [Direct mapping]
U4/U6 small nuclear ribonucleoprotein Prp31
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000244 [spliceosomal tri-snRNP complex assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005684 [U2-type spliceosomal complex]
GO:0005687 [U4 snRNP]
GO:0005690 [U4atac snRNP]
GO:0015030 [Cajal body]
GO:0016607 [nuclear speck]
GO:0030621 [U4 snRNA binding]
GO:0030622 [U4atac snRNA binding]
GO:0043021 [ribonucleoprotein complex binding]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0070990 [snRNP binding]
GO:0071011 [precatalytic spliceosome]
GO:0071339 [MLL1 complex]
Show all
 491 aa
54.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.