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JAK3

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GENERAL INFORMATION

Gene name

 JAK3

Gene description

 Janus kinase 3

Protein class

 Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the cytosol.

RNA cell category

 Cell line enhanced (HDLM-2, Karpas-707, U-937, U-266/84)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA070314
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2, Karpas-707, U-937, U-266/84)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the cytosol.

Main location

 Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA070314 REH Cytosol

GENE INFORMATION

Gene name

 JAK3 (HGNC Symbol)

Synonyms

 JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK

Description

 Janus kinase 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 17824780 - 17848071

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105639 (version 83.38)

Entrez gene

 3718

UniProt

 P52333 (UniProt - Evidence at protein level)

neXtProt

 NX_P52333

Antibodypedia

 JAK3 antibodies

PROTEIN BROWSER
JAK3-001
JAK3-005
JAK3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
JAK3-001
ENSP00000436421
ENST00000534444
P52333 [Direct mapping]
Tyrosine-protein kinase JAK3
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002250 [adaptive immune response]
GO:0002731 [negative regulation of dendritic cell cytokine production]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007167 [enzyme linked receptor protein signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007260 [tyrosine phosphorylation of STAT protein]
GO:0007262 [STAT protein import into nucleus]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019903 [protein phosphatase binding]
GO:0030183 [B cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032695 [negative regulation of interleukin-12 production]
GO:0035556 [intracellular signal transduction]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043029 [T cell homeostasis]
GO:0045087 [innate immune response]
GO:0045221 [negative regulation of FasL biosynthetic process]
GO:0045626 [negative regulation of T-helper 1 cell differentiation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050868 [negative regulation of T cell activation]
GO:0051427 [hormone receptor binding]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070232 [regulation of T cell apoptotic process]
GO:0070244 [negative regulation of thymocyte apoptotic process]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070672 [response to interleukin-15]
GO:0071104 [response to interleukin-9]
Show all
 1094 aa
121.3 kDa 		No 0
JAK3-005
ENSP00000432511
ENST00000527670
P52333 [Direct mapping]
Tyrosine-protein kinase JAK3
A0A024R7M7 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002250 [adaptive immune response]
GO:0002731 [negative regulation of dendritic cell cytokine production]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007167 [enzyme linked receptor protein signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007260 [tyrosine phosphorylation of STAT protein]
GO:0007262 [STAT protein import into nucleus]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019903 [protein phosphatase binding]
GO:0030183 [B cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032695 [negative regulation of interleukin-12 production]
GO:0035556 [intracellular signal transduction]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042981 [regulation of apoptotic process]
GO:0043029 [T cell homeostasis]
GO:0045087 [innate immune response]
GO:0045221 [negative regulation of FasL biosynthetic process]
GO:0045626 [negative regulation of T-helper 1 cell differentiation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050868 [negative regulation of T cell activation]
GO:0051427 [hormone receptor binding]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070232 [regulation of T cell apoptotic process]
GO:0070244 [negative regulation of thymocyte apoptotic process]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070672 [response to interleukin-15]
GO:0071104 [response to interleukin-9]
Show all
 1124 aa
125.1 kDa 		No 0
JAK3-201
ENSP00000391676
ENST00000458235
P52333 [Direct mapping]
Tyrosine-protein kinase JAK3
A0A024R7M7 [Target identity:100%; Query identity:100%]
Tyrosine-protein kinase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0002250 [adaptive immune response]
GO:0002731 [negative regulation of dendritic cell cytokine production]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006468 [protein phosphorylation]
GO:0007167 [enzyme linked receptor protein signaling pathway]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007260 [tyrosine phosphorylation of STAT protein]
GO:0007262 [STAT protein import into nucleus]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0012505 [endomembrane system]
GO:0016020 [membrane]
GO:0016477 [cell migration]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019903 [protein phosphatase binding]
GO:0030183 [B cell differentiation]
GO:0030218 [erythrocyte differentiation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0032693 [negative regulation of interleukin-10 production]
GO:0032695 [negative regulation of interleukin-12 production]
GO:0035556 [intracellular signal transduction]
GO:0035771 [interleukin-4-mediated signaling pathway]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042506 [tyrosine phosphorylation of Stat5 protein]
GO:0042981 [regulation of apoptotic process]
GO:0043029 [T cell homeostasis]
GO:0045087 [innate immune response]
GO:0045221 [negative regulation of FasL biosynthetic process]
GO:0045626 [negative regulation of T-helper 1 cell differentiation]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050778 [positive regulation of immune response]
GO:0050868 [negative regulation of T cell activation]
GO:0051427 [hormone receptor binding]
GO:0051928 [positive regulation of calcium ion transport]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070232 [regulation of T cell apoptotic process]
GO:0070244 [negative regulation of thymocyte apoptotic process]
GO:0070669 [response to interleukin-2]
GO:0070670 [response to interleukin-4]
GO:0070672 [response to interleukin-15]
GO:0071104 [response to interleukin-9]
Show all
 1124 aa
125.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.