Cell atlas - RPL18A - The Human Protein Atlas

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RPL18A

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CELL CYCLE

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoli

Human cell
	Cytosol
	Nucleoli

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GENERAL INFORMATION
Gene name	RPL18A
Gene description	Ribosomal protein L18a
Protein class	Plasma proteins Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoli. In addition localized to the nucleus & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by correlation analysis

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055259
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoli. In addition localized to the nucleus & cytosol.

Main location

Nucleoli (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055259	A549	Nucleus
	HPA055259	A549	Nucleoli
	HPA055259	CACO-2	Nucleus
	HPA055259	CACO-2	Nucleoli
	HPA055259	U-2 OS	Nucleoli	Spatial	Spatial
			Endoplasmic reticulum
			Cytosol	Spatial	Spatial

CELL CYCLE
Summary	Expression has cell cycle dependency according to correlation analysis
Spatial variation	Cytosol, Nucleoli
HPA055259

GENE INFORMATION
Gene name	RPL18A (HGNC Symbol)
Synonyms	L18A
Description	Ribosomal protein L18a (HGNC Symbol)
Entrez gene summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18AE family of ribosomal proteins that is a component of the 60S subunit. The encoded protein may play a role in viral replication by interacting with the hepatitis C virus internal ribosome entry site (IRES). This gene is co-transcribed with the U68 snoRNA, located within the third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. [provided by RefSeq, Jul 2012]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	17859876 - 17864153
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105640 (version 83.38)
Entrez gene	6142
UniProt	Q02543 (UniProt - Evidence at protein level)
neXtProt	NX_Q02543
Antibodypedia	RPL18A antibodies

PROTEIN BROWSER

RPL18A-001	RPL18A-002	RPL18A-005	RPL18A-007	RPL18A-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPL18A-001 ENSP00000222247 ENST00000222247	Q02543 [Direct mapping] 60S ribosomal protein L18a Show all	Ribosomal proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016032 [viral process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0022625 [cytosolic large ribosomal subunit] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] Show all	176 aa 20.8 kDa	No	0
RPL18A-002 ENSP00000471584 ENST00000600147	M0R117 [Direct mapping] 60S ribosomal protein L18a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	154 aa 18.1 kDa	No	0
RPL18A-005 ENSP00000471748 ENST00000599870	M0R1A7 [Direct mapping] 60S ribosomal protein L18a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	147 aa 17.5 kDa	No	0
RPL18A-007 ENSP00000473155 ENST00000597648	M0R3D6 [Direct mapping] 60S ribosomal protein L18a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	141 aa 16.7 kDa	No	0
RPL18A-008 ENSP00000471360 ENST00000599898	M0R0P7 [Direct mapping] 60S ribosomal protein L18a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	137 aa 16.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.