Expression of SLC5A5 in cancer - Summary

GENERAL INFORMATION
Gene name	SLC5A5
Gene description	Solute carrier family 5 (sodium/iodide cotransporter), member 5
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (BEWO)
HPA (normal tissue):	Tissue enhanced (salivary gland, stomach, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic and membranous expression, most abundant in thyroid gland, salivary ducts and stomach.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA049055 , CAB022364
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA049055	CAB022364

GENE INFORMATION
Gene name	SLC5A5 (HGNC Symbol)
Synonyms	NIS
Description	Solute carrier family 5 (sodium/iodide cotransporter), member 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.[provided by RefSeq, Sep 2009]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	17871973 - 17895174
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105641 (version 83.38)
Entrez gene	6528
UniProt	Q92911 (UniProt - Evidence at protein level)
neXtProt	NX_Q92911
Antibodypedia	SLC5A5 antibodies

PROTEIN BROWSER

SLC5A5-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC5A5-001 ENSP00000222248 ENST00000222248	Q92911 [Direct mapping] Sodium/iodide cotransporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Show all	GO:0005215 [transporter activity] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006590 [thyroid hormone generation] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006814 [sodium ion transport] GO:0008507 [sodium:iodide symporter activity] GO:0015111 [iodide transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015705 [iodide transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034641 [cellular nitrogen compound metabolic process] GO:0035725 [sodium ion transmembrane transport] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0071320 [cellular response to cAMP] GO:0071371 [cellular response to gonadotropin stimulus] GO:0098656 [anion transmembrane transport] GO:1903561 [extracellular vesicle] Show all	643 aa 68.7 kDa	No	>9