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RAB3A

GENERAL INFORMATION

Gene name

 RAB3A

Gene description

 RAB3A, member RAS oncogene family

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SCLC-21H, U-2197)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective expression in CNS, islets of Langerhans and adrenal medulla.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA003160 , CAB009949
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003160
CAB009949

GENE INFORMATION

Gene name

 RAB3A

Synonyms

Description

 RAB3A, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 18196784 - 18204074

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105649 (version 83.38)

Entrez gene

 5864

UniProt

 P20336 (UniProt - Evidence at protein level)

neXtProt

 NX_P20336

Antibodypedia

 RAB3A antibodies

PROTEIN BROWSER
RAB3A-001
RAB3A-002
RAB3A-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB3A-001
ENSP00000222256
ENST00000222256
P20336 [Direct mapping]
Ras-related protein Rab-3A
A0A024R7I7 [Target identity:100%; Query identity:100%]
H.sapiens ras-related Hrab3A protein; RAB3A, member RAS oncogene family, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001669 [acrosomal vesicle]
GO:0001671 [ATPase activator activity]
GO:0003016 [respiratory system process]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0006913 [nucleocytoplasmic transport]
GO:0007005 [mitochondrion organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007274 [neuromuscular synaptic transmission]
GO:0007409 [axonogenesis]
GO:0008021 [synaptic vesicle]
GO:0008022 [protein C-terminus binding]
GO:0009306 [protein secretion]
GO:0009791 [post-embryonic development]
GO:0014047 [glutamate secretion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0016188 [synaptic vesicle maturation]
GO:0017157 [regulation of exocytosis]
GO:0030324 [lung development]
GO:0030424 [axon]
GO:0030667 [secretory granule membrane]
GO:0031489 [myosin V binding]
GO:0031630 [regulation of synaptic vesicle fusion to presynaptic membrane]
GO:0032482 [Rab protein signal transduction]
GO:0032781 [positive regulation of ATPase activity]
GO:0036465 [synaptic vesicle recycling]
GO:0043195 [terminal bouton]
GO:0043229 [intracellular organelle]
GO:0043234 [protein complex]
GO:0045054 [constitutive secretory pathway]
GO:0045921 [positive regulation of exocytosis]
GO:0048172 [regulation of short-term neuronal synaptic plasticity]
GO:0048790 [maintenance of presynaptic active zone structure]
GO:0050975 [sensory perception of touch]
GO:0051020 [GTPase binding]
GO:0051117 [ATPase binding]
GO:0051602 [response to electrical stimulus]
GO:0060201 [clathrin-sculpted acetylcholine transport vesicle membrane]
GO:0060203 [clathrin-sculpted glutamate transport vesicle membrane]
GO:0061202 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
GO:0061670 [evoked neurotransmitter secretion]
GO:0070083 [clathrin-sculpted monoamine transport vesicle membrane]
GO:1903307 [positive regulation of regulated secretory pathway]
GO:1903561 [extracellular vesicle]
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 220 aa
25 kDa 		No 0
RAB3A-002
ENSP00000474603
ENST00000464076
S4R3Q3 [Direct mapping]
Ras-related protein Rab-3A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0016079 [synaptic vesicle exocytosis]
GO:0030667 [secretory granule membrane]
GO:0032482 [Rab protein signal transduction]
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 125 aa
14.1 kDa 		No 0
RAB3A-003
ENSP00000472335
ENST00000481914
M0R257 [Direct mapping]
Ras-related protein Rab-3A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005768 [endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006904 [vesicle docking involved in exocytosis]
GO:0007264 [small GTPase mediated signal transduction]
GO:0009306 [protein secretion]
GO:0015031 [protein transport]
GO:0016079 [synaptic vesicle exocytosis]
GO:0030667 [secretory granule membrane]
GO:0032482 [Rab protein signal transduction]
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 115 aa
13.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.