Expression of PDE4C in cancer - Summary - The Human Protein Atlas

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PDE4C

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PDE4C
Gene description	Phosphodiesterase 4C, cAMP-specific
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (BEWO, U-87 MG)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA048975
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048975

GENE INFORMATION
Gene name	PDE4C (HGNC Symbol)
Synonyms	DPDE1
Description	Phosphodiesterase 4C, cAMP-specific (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18207961 - 18255419
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105650 (version 83.38)
Entrez gene	5143
UniProt	Q08493 (UniProt - Evidence at protein level)
neXtProt	NX_Q08493
Antibodypedia	PDE4C antibodies

PROTEIN BROWSER

PDE4C-001	PDE4C-002	PDE4C-003	PDE4C-004	PDE4C-005	PDE4C-007	PDE4C-008	PDE4C-010	PDE4C-016	PDE4C-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDE4C-001 ENSP00000347689 ENST00000355502	Q08493 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4C Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115 [3',5'-cyclic-AMP phosphodiesterase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0008144 [drug binding] GO:0046676 [negative regulation of insulin secretion] GO:0046872 [metal ion binding] GO:0072372 [primary cilium] Show all	712 aa 79.9 kDa	No	0
PDE4C-002 ENSP00000469696 ENST00000594617	Q08493 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4C Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0046872 [metal ion binding] GO:0072372 [primary cilium] Show all	712 aa 79.9 kDa	No	0
PDE4C-003 ENSP00000470210 ENST00000594465	Q08493 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4C Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0046872 [metal ion binding] GO:0072372 [primary cilium] Show all	712 aa 79.9 kDa	No	0
PDE4C-004 ENSP00000262805 ENST00000262805	Q08493 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4C Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0046872 [metal ion binding] GO:0072372 [primary cilium] Show all	680 aa 75.6 kDa	No	0
PDE4C-005 ENSP00000402091 ENST00000447275	Q08493 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4C Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0046872 [metal ion binding] GO:0072372 [primary cilium] Show all	606 aa 67.8 kDa	No	0
PDE4C-007 ENSP00000476923 ENST00000597297	V9GYN0 [Direct mapping] Phosphodiesterase 4C, cAMP-specific (Phosphodiesterase E1 dunce homolog, Drosophila), isoform CRA_d; cAMP-specific 3',5'-cyclic phosphodiesterase 4C Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] Show all	482 aa 54.3 kDa	No	0
PDE4C-008 ENSP00000474591 ENST00000598111	O76104 [Direct mapping] PDE4C-delta109; cAMP-specific 3',5'-cyclic phosphodiesterase 4C Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] Show all	427 aa 48.2 kDa	No	0
PDE4C-010 ENSP00000472034 ENST00000599754	M0R1P5 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		93 aa 10.8 kDa	No	0
PDE4C-016 ENSP00000476961 ENST00000610023	V9GYP2 [Direct mapping] cAMP-specific 3',5'-cyclic phosphodiesterase 4C Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		82 aa 8.9 kDa	No	0
PDE4C-201 ENSP00000439470 ENST00000539010	Q32MM7 [Direct mapping] PDE4C protein; cAMP-specific 3',5'-cyclic phosphodiesterase 4C Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] Show all	481 aa 54.2 kDa	No	0

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