Tissue expression of COMP - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	COMP
Gene description	Cartilage oligomeric matrix protein
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (gallbladder)
GTEx:	Tissue enhanced (adipose tissue, skin)
FANTOM5:	Tissue enhanced (adipose tissue, skeletal muscle)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (gallbladder)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue, skin)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (adipose tissue, skeletal muscle)

GENE INFORMATION
Gene name	COMP (HGNC Symbol)
Synonyms	EDM1, EPD1, MED, PSACH, THBS5
Description	Cartilage oligomeric matrix protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	18782773 - 18791314
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105664 (version 83.38)
Entrez gene	1311
UniProt	P49747 (UniProt - Evidence at protein level)
neXtProt	NX_P49747
Antibodypedia	COMP antibodies

PROTEIN BROWSER

COMP-001	COMP-005	COMP-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COMP-001 ENSP00000222271 ENST00000222271	P49747 [Direct mapping] Cartilage oligomeric matrix protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0002020 [protease binding] GO:0003417 [growth plate cartilage development] GO:0005201 [extracellular matrix structural constituent] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0006915 [apoptotic process] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0009887 [organ morphogenesis] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0043066 [negative regulation of apoptotic process] GO:0043395 [heparan sulfate proteoglycan binding] GO:0060173 [limb development] GO:0070062 [extracellular exosome] Show all	757 aa 82.9 kDa	Yes	0
COMP-005 ENSP00000403792 ENST00000425807	P49747 [Direct mapping] Cartilage oligomeric matrix protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0002020 [protease binding] GO:0005201 [extracellular matrix structural constituent] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005518 [collagen binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0006915 [apoptotic process] GO:0007155 [cell adhesion] GO:0008201 [heparin binding] GO:0009887 [organ morphogenesis] GO:0030198 [extracellular matrix organization] GO:0031012 [extracellular matrix] GO:0043066 [negative regulation of apoptotic process] GO:0043395 [heparan sulfate proteoglycan binding] GO:0060173 [limb development] GO:0070062 [extracellular exosome] Show all	704 aa 77.2 kDa	Yes	0
COMP-007 ENSP00000439156 ENST00000542601	G3XAP6 [Direct mapping] Cartilage oligomeric matrix protein; Cartilage oligomeric matrix protein, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007155 [cell adhesion] Show all	724 aa 79.7 kDa	No	0