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UPK1A

GENERAL INFORMATION

Gene name

 UPK1A

Gene description

 Uroplakin 1A

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (urothelial cancer)
HPA (cell line):Cell line enriched (RT4)
HPA (normal tissue):Tissue enhanced (esophagus, urinary bladder)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in umbrella cells in urinary bladder.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA049879
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049879

GENE INFORMATION

Gene name

 UPK1A (HGNC Symbol)

Synonyms

 TSPAN21

Description

 Uroplakin 1A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Chromosome

 19

Cytoband

 q13.12

Chromosome location (bp)

 35666516 - 35678483

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105668 (version 83.38)

Entrez gene

 11045

UniProt

 O00322 (UniProt - Evidence at transcript level)

neXtProt

 NX_O00322

Antibodypedia

 UPK1A antibodies

PROTEIN BROWSER
UPK1A-001
UPK1A-002
UPK1A-201
UPK1A-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UPK1A-001
ENSP00000222275
ENST00000222275
O00322 [Direct mapping]
Uroplakin-1a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Show all
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0030855 [epithelial cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0048029 [monosaccharide binding]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
Show all
 258 aa
28.9 kDa 		No 4
UPK1A-002
ENSP00000368298
ENST00000379013
O00322 [Direct mapping]
Uroplakin-1a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0030855 [epithelial cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0048029 [monosaccharide binding]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
Show all
 273 aa
30 kDa 		No 3
UPK1A-201
ENSP00000478942
ENST00000616789
O00322 [Direct mapping]
Uroplakin-1a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0030855 [epithelial cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0048029 [monosaccharide binding]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
Show all
 273 aa
30 kDa 		No 3
UPK1A-202
ENSP00000483176
ENST00000617999
O00322 [Direct mapping]
Uroplakin-1a
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0030855 [epithelial cell differentiation]
GO:0042803 [protein homodimerization activity]
GO:0048029 [monosaccharide binding]
GO:0051259 [protein oligomerization]
GO:0070062 [extracellular exosome]
Show all
 258 aa
28.9 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.