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COPE

GENERAL INFORMATION

Gene name

 COPE

Gene description

 Coatomer protein complex, subunit epsilon

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA041605 , HPA043576 , CAB034345
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable).
0.00.10.20.30.40.50.60.70.80.91.0 0 1 2 3 4 5 6 7 8 91011121314151617 Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all
0.050100150200250300FPKMBreast cancer (BRCA)Cervical cancer (CESC)Colorectal cancer (COAD,READ)Endometrial cancer (UCEC)Glioma (GBM)Head and neck cancer (HNSC)Liver cancer (LIHC)Lung cancer (LUAD,LUSC)Melanoma (SKCM)Ovarian cancer (OV)Pancreatic cancer (PAAD)Prostate cancer (PRAD)Renal cancer (KICH,KIRC,KIRP)Stomach cancer (STAD)Testis cancer (TGCT)Thyroid cancer (THCA)Urothelial cancer (BLCA)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041605
HPA043576
CAB034345

Cancer

Cancer staining

Protein
expression of
normal tissue
Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue
Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

 Most of the cancer cells showed moderate to strong cytoplasmic immunoreactivity. Several lymphomas, skin, testis and renal cancers were weakly stained or negative.

GENE INFORMATION

Gene name

 COPE (HGNC Symbol)

Synonyms

 epsilon-COP

Description

 Coatomer protein complex, subunit epsilon (HGNC Symbol)

Entrez gene summary

 The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 18899514 - 18919397

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105669 (version 83.38)

Entrez gene

 11316

UniProt

 O14579 (UniProt - Evidence at protein level)

neXtProt

 NX_O14579

Antibodypedia

 COPE antibodies

PROTEIN BROWSER
COPE-001
COPE-002
COPE-004
COPE-005
COPE-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COPE-001
ENSP00000262812
ENST00000262812
O14579 [Direct mapping]
Coatomer subunit epsilon
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0015031 [protein transport]
GO:0030126 [COPI vesicle coat]
GO:0030137 [COPI-coated vesicle]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0061024 [membrane organization]
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 308 aa
34.5 kDa 		No 0
COPE-002
ENSP00000345674
ENST00000351079
O14579 [Direct mapping]
Coatomer subunit epsilon
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0015031 [protein transport]
GO:0030126 [COPI vesicle coat]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0061024 [membrane organization]
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 257 aa
28.8 kDa 		No 0
COPE-004
ENSP00000469035
ENST00000600932
M0QXB4 [Direct mapping]
Coatomer protein complex, subunit epsilon, isoform CRA_g; Coatomer subunit epsilon
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0030126 [COPI vesicle coat]
Show all
 331 aa
36.9 kDa 		No 0
COPE-005
ENSP00000343134
ENST00000349893
O14579 [Direct mapping]
Coatomer subunit epsilon
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0015031 [protein transport]
GO:0030126 [COPI vesicle coat]
GO:0048205 [COPI coating of Golgi vesicle]
GO:0061024 [membrane organization]
Show all
 256 aa
28.8 kDa 		No 0
COPE-201
ENSP00000483420
ENST00000614388
A0A087X0I4 [Direct mapping]
Coatomer subunit epsilon
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006890 [retrograde vesicle-mediated transport, Golgi to ER]
GO:0006891 [intra-Golgi vesicle-mediated transport]
GO:0030126 [COPI vesicle coat]
Show all
 307 aa
34.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.