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GAPDHS

GENERAL INFORMATION

Gene name

 GAPDHS

Gene description

 Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (melanoma)
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in spermatozoa.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA042666
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA042666

GENE INFORMATION

Gene name

 GAPDHS (HGNC Symbol)

Synonyms

 GAPD2, GAPDH-2, GAPDS

Description

 Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.12

Chromosome location (bp)

 35533412 - 35545316

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105679 (version 83.38)

Entrez gene

 26330

UniProt

 O14556 (UniProt - Evidence at protein level)

neXtProt

 NX_O14556

Antibodypedia

 GAPDHS antibodies

PROTEIN BROWSER
GAPDHS-001
GAPDHS-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GAPDHS-001
ENSP00000222286
ENST00000222286
O14556 [Direct mapping]
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
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Enzymes
   ENZYME proteins
   Oxidoreductases
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004365 [glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005929 [cilium]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0007286 [spermatid development]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0030317 [sperm motility]
GO:0031514 [motile cilium]
GO:0035686 [sperm fibrous sheath]
GO:0044281 [small molecule metabolic process]
GO:0045821 [positive regulation of glycolytic process]
GO:0050661 [NADP binding]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0061621 [canonical glycolysis]
GO:0097228 [sperm principal piece]
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 408 aa
44.5 kDa 		No 0
GAPDHS-004
ENSP00000467255
ENST00000585510
K7EP73 [Direct mapping]
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0055114 [oxidation-reduction process]
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 179 aa
19.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.