Expression of MAG in cancer - Summary - The Human Protein Atlas

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MAG

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAG
Gene description	Myelin associated glycoprotein
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Cell line enriched (WM-115)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in the CNS and in peripheral nerves.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA012499 , CAB009345
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012499	CAB009345

GENE INFORMATION
Gene name	MAG (HGNC Symbol)
Synonyms	GMA, S-MAG, SIGLEC-4A, SIGLEC4A
Description	Myelin associated glycoprotein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2010]
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35292125 - 35313804
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105695 (version 83.38)
Entrez gene	4099
UniProt	P20916 (UniProt - Evidence at protein level)
neXtProt	NX_P20916
Antibodypedia	MAG antibodies

PROTEIN BROWSER

MAG-001	MAG-002	MAG-003	MAG-004	MAG-005	MAG-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAG-001 ENSP00000376048 ENST00000392213	P20916 [Direct mapping] Myelin-associated glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007399 [nervous system development] GO:0007596 [blood coagulation] GO:0010977 [negative regulation of neuron projection development] GO:0016021 [integral component of membrane] GO:0019901 [protein kinase binding] GO:0021762 [substantia nigra development] GO:0030246 [carbohydrate binding] GO:0031643 [positive regulation of myelination] GO:0033270 [paranode region of axon] GO:0035749 [myelin sheath adaxonal region] GO:0043209 [myelin sheath] GO:0043220 [Schmidt-Lanterman incisure] GO:0045665 [negative regulation of neuron differentiation] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048711 [positive regulation of astrocyte differentiation] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0050900 [leukocyte migration] GO:0071260 [cellular response to mechanical stimulus] GO:0097453 [mesaxon] Show all	626 aa 69.1 kDa	Yes	1
MAG-002 ENSP00000355234 ENST00000361922	P20916 [Direct mapping] Myelin-associated glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0021762 [substantia nigra development] GO:0030246 [carbohydrate binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0050900 [leukocyte migration] Show all	582 aa 64 kDa	Yes	1
MAG-003 ENSP00000440695 ENST00000537831	P20916 [Direct mapping] Myelin-associated glycoprotein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0021762 [substantia nigra development] GO:0030246 [carbohydrate binding] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0050771 [negative regulation of axonogenesis] GO:0050900 [leukocyte migration] Show all	601 aa 66.2 kDa	No	1
MAG-004 ENSP00000470772 ENST00000600291	M0QZU4 [Direct mapping] Myelin-associated glycoprotein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	131 aa 14.6 kDa	No	0
MAG-005 ENSP00000473125 ENST00000595791	M0R3B9 [Direct mapping] Myelin-associated glycoprotein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	158 aa 17.6 kDa	Yes	0
MAG-006 ENSP00000473245 ENST00000597035	M0R3I4 [Direct mapping] Myelin-associated glycoprotein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.4 kDa	Yes	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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