Expression of LSR in cancer - Summary - The Human Protein Atlas

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LSR

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LSR
Gene description	Lipolysis stimulated lipoprotein receptor
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (A-431)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA007270
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007270

GENE INFORMATION
Gene name	LSR (HGNC Symbol)
Synonyms	ILDR3, LISCH7
Description	Lipolysis stimulated lipoprotein receptor (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.12
Chromosome location (bp)	35248330 - 35267964
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000105699 (version 83.38)
Entrez gene	51599
UniProt	Q86X29 (UniProt - Evidence at protein level)
neXtProt	NX_Q86X29
Antibodypedia	LSR antibodies

PROTEIN BROWSER

LSR-001	LSR-002	LSR-003	LSR-004	LSR-005	LSR-006	LSR-007	LSR-010	LSR-012	LSR-013	LSR-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LSR-001 ENSP00000472569 ENST00000602122	Q86X29 [Direct mapping] Lipolysis-stimulated lipoprotein receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034361 [very-low-density lipoprotein particle] GO:0034362 [low-density lipoprotein particle] GO:0042627 [chylomicron] GO:0070062 [extracellular exosome] Show all	629 aa 69.4 kDa	No	2
LSR-002 ENSP00000262627 ENST00000347609	Q86X29 [Direct mapping] Lipolysis-stimulated lipoprotein receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034361 [very-low-density lipoprotein particle] GO:0034362 [low-density lipoprotein particle] GO:0042627 [chylomicron] GO:0070062 [extracellular exosome] Show all	591 aa 65.6 kDa	No	1
LSR-003 ENSP00000354575 ENST00000361790	Q86X29 [Direct mapping] Lipolysis-stimulated lipoprotein receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034361 [very-low-density lipoprotein particle] GO:0034362 [low-density lipoprotein particle] GO:0042627 [chylomicron] GO:0070062 [extracellular exosome] Show all	649 aa 71.4 kDa	No	2
LSR-004 ENSP00000354034 ENST00000360798	Q86X29 [Direct mapping] Lipolysis-stimulated lipoprotein receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034361 [very-low-density lipoprotein particle] GO:0034362 [low-density lipoprotein particle] GO:0042627 [chylomicron] GO:0070062 [extracellular exosome] Show all	581 aa 64.1 kDa	No	1
LSR-005 ENSP00000394479 ENST00000427250	Q86X29 [Direct mapping] Lipolysis-stimulated lipoprotein receptor Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034361 [very-low-density lipoprotein particle] GO:0034362 [low-density lipoprotein particle] GO:0042627 [chylomicron] GO:0070062 [extracellular exosome] Show all	493 aa 54.5 kDa	Yes	0
LSR-006 ENSP00000472154 ENST00000601623	M0R1W9 [Direct mapping] Lipolysis-stimulated lipoprotein receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	139 aa 15.3 kDa	No	1
LSR-007 ENSP00000471486 ENST00000602003	M0R0W1 [Direct mapping] Lipolysis-stimulated lipoprotein receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		51 aa 5.4 kDa	No	0
LSR-010 ENSP00000470630 ENST00000599658	M0QZL9 [Direct mapping] Lipolysis-stimulated lipoprotein receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	114 aa 12 kDa	No	0
LSR-012 ENSP00000346976 ENST00000354900	Q86X29 [Direct mapping] Lipolysis-stimulated lipoprotein receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0034361 [very-low-density lipoprotein particle] GO:0034362 [low-density lipoprotein particle] GO:0042627 [chylomicron] GO:0070062 [extracellular exosome] Show all	630 aa 69.6 kDa	No	2
LSR-013 ENSP00000474797 ENST00000605618	S4R3V8 [Direct mapping] Lipolysis-stimulated lipoprotein receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	601 aa 66.2 kDa	No	1
LSR-201 ENSP00000480821 ENST00000621372	Q86X29 [Direct mapping] Lipolysis-stimulated lipoprotein receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0019216 [regulation of lipid metabolic process] GO:0034361 [very-low-density lipoprotein particle] GO:0034362 [low-density lipoprotein particle] GO:0042627 [chylomicron] GO:0070062 [extracellular exosome] Show all	649 aa 71.4 kDa	No	2

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The Human Protein Atlas

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