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FKBP8

GENERAL INFORMATION

Gene name

 FKBP8

Gene description

 FK506 binding protein 8, 38kDa

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in most cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA045177 , CAB025346
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (unfavourable) and pancreatic cancer (favourable).
Colorectal cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045177
CAB025346

GENE INFORMATION

Gene name

 FKBP8 (HGNC Symbol)

Synonyms

 FKBP38, FKBPr38

Description

 FK506 binding protein 8, 38kDa (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.11

Chromosome location (bp)

 18531751 - 18544077

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000105701 (version 83.38)

Entrez gene

 23770

UniProt

 Q14318 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14318

Antibodypedia

 FKBP8 antibodies

PROTEIN BROWSER
«
FKBP8-001
FKBP8-002
FKBP8-004
FKBP8-006
FKBP8-007
FKBP8-008
FKBP8-009
FKBP8-011
FKBP8-013
FKBP8-014
FKBP8-015
FKBP8-016
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FKBP8-001
ENSP00000471700
ENST00000597960
Q14318 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP8
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0031966 [mitochondrial membrane]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0046872 [metal ion binding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 413 aa
44.6 kDa 		No 1
FKBP8-002
ENSP00000472302
ENST00000596558
Q14318 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP8
A0A024R7P2 [Target identity:100%; Query identity:100%]
FK506 binding protein 8, 38kDa, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0031966 [mitochondrial membrane]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0046872 [metal ion binding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 412 aa
44.6 kDa 		No 1
FKBP8-004
ENSP00000441267
ENST00000544835
A0A0A0MTJ1 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0061077 [chaperone-mediated protein folding]
Show all
 249 aa
27.1 kDa 		No 1
FKBP8-006
ENSP00000472643
ENST00000597611
M0R2K9 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 257 aa
27.5 kDa 		No 0
FKBP8-007
ENSP00000472087
ENST00000594844
M0R1S6 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 168 aa
17.9 kDa 		No 0
FKBP8-008
ENSP00000472731
ENST00000599540
M0R2Q6 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 204 aa
21.8 kDa 		No 0
FKBP8-009
ENSP00000472043
ENST00000597547
M0R1Q0 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 163 aa
17.4 kDa 		No 0
FKBP8-011
ENSP00000475588
ENST00000596015
U3KQ64 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0016021 [integral component of membrane]
GO:0061077 [chaperone-mediated protein folding]
Show all
 182 aa
19.9 kDa 		No 1
FKBP8-013
ENSP00000477278
ENST00000609656
V9GZ05 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0061077 [chaperone-mediated protein folding]
Show all
 23 aa
2.3 kDa 		No 0
FKBP8-014
ENSP00000476767
ENST00000608443
Q14318 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP8
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0001708 [cell fate specification]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005740 [mitochondrial envelope]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0006915 [apoptotic process]
GO:0007224 [smoothened signaling pathway]
GO:0009953 [dorsal/ventral pattern formation]
GO:0010468 [regulation of gene expression]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0021904 [dorsal/ventral neural tube patterning]
GO:0021915 [neural tube development]
GO:0030176 [integral component of endoplasmic reticulum membrane]
GO:0030510 [regulation of BMP signaling pathway]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0031966 [mitochondrial membrane]
GO:0035264 [multicellular organism growth]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0043010 [camera-type eye development]
GO:0043066 [negative regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 413 aa
44.6 kDa 		No 1
FKBP8-015
ENSP00000475895
ENST00000606531
U3KQI1 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0061077 [chaperone-mediated protein folding]
Show all
 103 aa
11 kDa 		No 0
FKBP8-016
ENSP00000222308
ENST00000222308
Q14318 [Direct mapping]
Peptidyl-prolyl cis-trans isomerase FKBP8
A0A024R7P2 [Target identity:100%; Query identity:100%]
FK506 binding protein 8, 38kDa, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Isomerase
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization]
GO:0003755 [peptidyl-prolyl cis-trans isomerase activity]
GO:0005515 [protein binding]
GO:0005528 [FK506 binding]
GO:0005737 [cytoplasm]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006457 [protein folding]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0031966 [mitochondrial membrane]
GO:0035556 [intracellular signal transduction]
GO:0042802 [identical protein binding]
GO:0046872 [metal ion binding]
GO:0061077 [chaperone-mediated protein folding]
Show all
 412 aa
44.6 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.